The song was featured in the Superman TV series Smallville in episode "Stray" (1.16) in Season 1 and during the intro "Hereafter" (3.12) in Season 3. At the end of the song's music video, John Ondrasik lies in bed with his own wife and son.
In his 2010 comedy tour, Conan O'Brien sang a cover of the song by himself before Jim Carrey appeared in a Superman suit and the two men sang a duet.
The song is also featured in on Dawson's Creek in season four, episode two, and on the second Dawson's Creek soundtrack.
The song was the backing track to BBC Match of the Day's "The Story So Far", bringing the group stages of the World Cup to an end.
An anonymous cover was played on the seventh series of The X Factor after Liam Payne's audition. The singer of this version was speculated to be Joe McElderry, the winner of the previous series. This turned out to be true when the tracklist for his debut album Wide Awake was revealed. McElderry's version reached #56 in the UK chart on album downloads alone.
The song also appeared in the cartoon The Ambiguously Gay Duo, in the episode "The Third Leg of Justice". Bighead plays the song, causing Ace and Gary to dance and to cry in empathy.