Dark Angel: A group of genetically-enhanced children escape from a lab project. Years later we meet Max, one of the escapees who now works for a messenger service in the post-apocalyptic Pacific Northwest.
Captain America: The First Avenger is the 2011 film rendition of the Captain America franchise featuring Chris Evans. A scientist, Dr. Abraham Erskine, is commissioned by the United States military to counter the actions of the Nazi regime, with both sides looking to create a new fighting force. Dr. Erskine's method of creating a supersoldier involved injecting a top-secret serum of his own design, as well as bombarding the subject with "vita-rays", inducing massive muscle and skeletal growth and increased performance.
Crysis: A video game series started in 2007 featuring a near future with a massive alien-built structure found on the fictional Lingshan Islands near the East Philippines. As an elite soldier recruited from the United States Army's Delta Force, the main character, codenamed "Nomad", wears a Nano-Suit that provides the user a massive boost in combat capability and defensive stature. Using this technology, the player combats North Korean forces and extraterrestrial invaders known as the Ceph. Overtime, it is found that people who wear Nano-Suits begin to connect to it on a psychic and cellular level as seen in Crysis 2. The connection reaches the point where any attempt to completely remove the suit can be lethal. Furthermore, since the Nano-Suit was derived from Ceph technology and enhanced with Ceph DNA, the distinction between being a human wearing the powered exoskeleton or being a chimera is rapidly blurred as seen in Crysis 3.
F.E.A.R.: A psychological-horror video game series started in 2005, spanning a number of years and a variety of nightmare-fueled enemies, all centered around the main antagonist Alma Wade, a supernatural enemy using fear to destroy entire cities. The first game takes focus on supersoldiers, as the beginning plot is centered around The Pointman searching for a cannibal named Paxton Fettel who has taken control of Armacham Technology Corporation and their genetically-modified supersoldiers, who become the game's focal enemy.
Halo: The protagonist of the video game series is a supersoldier called a SPARTAN-II. Master Chief or John-117, as he is usually referred to, was taken as a child from his home on a human extrasolar colony and was replaced with a flawed clone that died soon afterwards, as were 74 other children; later he underwent extreme military training and special cybernetic augmentations to become a Spartan. Spartans not only have superhuman size and physical capacity, but are also recognizable by their trademark high-tech state-of-the-art MJOLNIR-series powered armor.
Prototype: An action-adventure video game from 2009 set in Manhattan in the midst of an outbreak of a virus called BLACKLIGHT. An enemy faction of the game, Blackwatch, deploys supersoldiers specializing in close combat. According to officers, they were exposed in controlled environments to the BLACKLIGHT virus, giving them superhuman strength, speed, and endurance. These enemies have titanic body structures, standing almost as tall as tanks, and are more than capable of fighting the protagonist with their bare hands, even being shown to heft large missiles with one hand and toss them like projectiles.
A similar example is a Clone Trooper from the Star Wars universe created from the DNA of bounty hunter Jango Fett. Though Fett is not genetically altered in anyway, he is a highly skilled fighter whose clones inherited his skills and were incorporated into the Old Republic as it's formal military. The clones roles were similar to that of supersoldiers.