Surfactant protein D

Surfactant protein D
	; PDB rendering based on 1b08.
Available structures
PDB	1B08, 1M7L, 1PW9, 1PWB, 2GGU, 2GGX, 2ORJ, 2ORK, 2OS9, 2RIA, 2RIB, 2RIC, 2RID, 2RIE, 3DBZ, 3G81, 3G83, 3G84, 3IKN, 3IKP, 3IKQ, 3IKR
Identifiers
Symbols	SFTPD; COLEC7; PSP-D; SFTP4; SP-D
External IDs	OMIM: 178635 MGI: 109515 HomoloGene: 2272 GeneCards: SFTPD Gene
Gene Ontology
Molecular function	• protein binding; • sugar binding; • bacterial cell surface binding;
Cellular component	• extracellular region; • collagen; • extracellular space; • lysosome; • endocytic vesicle;
Biological process	• regulation of cytokine production; • receptor-mediated endocytosis; • respiratory gaseous exchange; • cell junction assembly; • negative regulation of T cell proliferation; • surfactant homeostasis; • negative regulation of interleukin-2 biosynthetic process; • innate immune response; • macrophage chemotaxis; • lung alveolus development; • positive regulation of phagocytosis; • reactive oxygen species metabolic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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Surfactant, pulmonary-associated protein D, also known as SFTPD or SP-D, is a protein which in humans is encoded by the SFTPD gene.^[1]^[2]

SFTPD is an innate immune system collectin.^[3]^[4]

[edit] Interactions

Surfactant protein D has been shown to interact with DMBT1.^[5]^[6]

[edit] See also

pulmonary surfactant

[edit] External links

MeSH Surfactant+Protein+D

[edit] References

^ Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E (October 1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Arch. Biochem. Biophys. 290 (1): 116–26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081.
^ Lu J, Willis AC, Reid KB (June 1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D". Biochem. J.. 284 ( Pt 3): 795–802. PMC 1132609. PMID 1339284. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1132609.
^ "Entrez Gene: SFTPD surfactant, pulmonary-associated protein D". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6441.
^ Brandt EB, Mingler MK, Stevenson MD, Wang N, Khurana Hershey GK, Whitsett JA, Rothenberg ME (May 2008). "Surfactant protein D alters allergic lung responses in mice and human subjects". J. Allergy Clin. Immunol. 121 (5): 1140–1147.e2. doi:10.1016/j.jaci.2008.02.011. PMID 18355911.
^ Tino, M J; Wright J R (Apr. 1999). "Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner". Am. J. Respir. Cell Mol. Biol. (UNITED STATES) 20 (4): 759–68. ISSN 1044-1549. PMID 10101009.
^ Holmskov, U; Lawson P, Teisner B, Tornoe I, Willis A C, Morgan C, Koch C, Reid K B (May. 1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". J. Biol. Chem. (UNITED STATES) 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. ISSN 0021-9258. PMID 9153228.

[edit] Further reading

Hansen S, Holmskov U (1999). "Structural aspects of collectins and receptors for collectins.". Immunobiology 199 (2): 165–89. PMID 9777404.
Lu J, Willis AC, Reid KB (1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D.". Biochem. J.. 284 ( Pt 3): 795–802. PMC 1132609. PMID 1339284. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1132609.
Ogasawara Y, Kuroki Y, Akino T (1992). "Pulmonary surfactant protein D specifically binds to phosphatidylinositol.". J. Biol. Chem. 267 (29): 21244–9. PMID 1400434.
Rust K, Grosso L, Zhang V, et al. (1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain.". Arch. Biochem. Biophys. 290 (1): 116–26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081.
Kuroki Y, Shiratori M, Ogasawara Y, et al. (1991). "Characterization of pulmonary surfactant protein D: its copurification with lipids.". Biochim. Biophys. Acta 1086 (2): 185–90. PMID 1932100.
Crouch E, Persson A, Chang D, Heuser J (1994). "Molecular structure of pulmonary surfactant protein D (SP-D).". J. Biol. Chem. 269 (25): 17311–9. PMID 8006040.
Schaeffer E, Guillou F, Part D, Zakin MM (1993). "A different combination of transcription factors modulates the expression of the human transferrin promoter in liver and Sertoli cells.". J. Biol. Chem. 268 (31): 23399–408. PMID 8226864.
Kölble K, Lu J, Mole SE, et al. (1993). "Assignment of the human pulmonary surfactant protein D gene (SFTP4) to 10q22-q23 close to the surfactant protein A gene cluster.". Genomics 17 (2): 294–8. doi:10.1006/geno.1993.1324. PMID 8406480.
Crouch E, Persson A, Chang D (1993). "Accumulation of surfactant protein D in human pulmonary alveolar proteinosis.". Am. J. Pathol. 142 (1): 241–8. PMC 1886847. PMID 8424457. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1886847.
Crouch E, Rust K, Veile R, et al. (1993). "Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1.". J. Biol. Chem. 268 (4): 2976–83. PMID 8428971.
Rust K, Bingle L, Mariencheck W, et al. (1996). "Characterization of the human surfactant protein D promoter: transcriptional regulation of SP-D gene expression by glucocorticoids.". Am. J. Respir. Cell Mol. Biol. 14 (2): 121–30. PMID 8630261.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Holmskov U, Lawson P, Teisner B, et al. (1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule.". J. Biol. Chem. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID 9153228.
Botas C, Poulain F, Akiyama J, et al. (1998). "Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D.". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11869–74. doi:10.1073/pnas.95.20.11869. PMC 21732. PMID 9751757. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21732.
Håkansson K, Lim NK, Hoppe HJ, Reid KB (1999). "Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D.". Structure 7 (3): 255–64. doi:10.1016/S0969-2126(99)80036-7. PMID 10368295.
Holmskov U, Mollenhauer J, Madsen J, et al. (1999). "Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D.". Proc. Natl. Acad. Sci. U.S.A. 96 (19): 10794–9. doi:10.1073/pnas.96.19.10794. PMC 17962. PMID 10485905. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=17962.
Lausen M, Lynch N, Schlosser A, et al. (1999). "Microfibril-associated protein 4 is present in lung washings and binds to the collagen region of lung surfactant protein D.". J. Biol. Chem. 274 (45): 32234–40. doi:10.1074/jbc.274.45.32234. PMID 10542261.
Madsen J, Kliem A, Tornoe I, et al. (2000). "Localization of lung surfactant protein D on mucosal surfaces in human tissues.". J. Immunol. 164 (11): 5866–70. PMID 10820266.
Zhang L, Ikegami M, Crouch EC, et al. (2001). "Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure.". J. Biol. Chem. 276 (22): 19214–9. doi:10.1074/jbc.M010191200. PMID 11278637.