Suzuki reaction

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The Suzuki reaction is the organic reaction that is classified as a coupling reaction where the coupling partners are a boronic acid with a halide catalyzed by a palladium(0) complex.[1][2][3] It was first published in 1979 by Akira Suzuki and he shared the 2010 Nobel Prize in Chemistry with Richard F. Heck and Ei-ichi Negishi for their effort for discovery and development of palladium-catalyzed cross couplings in organic synthesis.[4] In many publications this reaction also goes by the name Suzuki–Miyaura reaction and is also referred to as the "Suzuki Coupling". It is widely used to synthesize poly-olefins, styrenes, and substituted biphenyls. Several reviews have been published describing advancements and the development of the Suzuki Reaction.[5][6][7] The general scheme for the Suzuki reaction is shown below where you form a carbon-carbon single bond by coupling a organoboron species (R1-BY2) with a halide (R2-X) using a palladium catalyst and a base.

The Suzuki reaction

Reaction mechanism[edit]

The mechanism of the Suzuki reaction is best viewed from the perspective of the palladium catalyst. The first step is the oxidative addition of palladium to the halide 2 to form the organopalladium species 3. Reaction with base gives intermediate 4, which via transmetalation[8] with the boron-ate complex 6 forms the organopalladium species 8. Reductive elimination of the desired product 9 restores the original palladium catalyst 1 which completes the catalytic cycle. The Suzuki coupling takes place in the presence of a base and for a long time the role of the base was never fully understood. The base was first believed to form a trialkyl borate (R3B-OR), in the case of a reaction of an trialkylborane (BR3) and alkoxide (-OR); this species could be considered as being more nucleophilic and then more reactive towards the palladium complex present in the transmetalation step.[9][10][11] Duc and coworkers investigated the role of the base in the reaction mechanism for the Suzuki coupling and they found that the base has three roles: Formation of the palladium complex [ArPd(OR)L2], formation of the trialkyl borate and the acceleration of the reductive elimination step by reaction of the alkoxide with the palladium complex.[9]

Suzuki Coupling Full Mechanism 2

Oxidative addition[edit]

Main article: Oxidative Addition

In most cases the oxidative Addition is the rate determining step of the catalytic cycle.[12] During this step, the palladium catalyst is oxidized from palladium(0) to palladium(II). The palladium catalyst 1 is coupled with the alkyl halide 2 to yield an organopalladium complex 3. As you can see in the diagram the oxidative addition step breaks the carbon-halogen bond where the palladium is now bound to both the halogen and the R group.

Suzuki Coupling Oxidative Addition

Oxidative addition proceeds with retention of stereochemistry with vinyl halides, while giving inversion of stereochemistry with allylic and benzylic halides.[13] The oxidative addition initially forms the cis–palladium complex, which rapidly isomerizes to the trans-complex.[14]

CisTrans Palladium Complex

The Suzuki Coupling occurs with retention of configuration on the double bonds for both the organoboron reagent or the halide.[15] However, the configuration of that double bond, cis or trans is determined by the cis-to-trans isomerization of the palladium complex in the oxidative addition step where the trans palladium complex is the predominant form. When the organoboron is attached to a double bond and it is coupled to an alkenyl halide the product is a diene as shown below.

Suzuki Double Bond Three

Transmetalation[edit]

Main article: Transmetalation

Transmetalation is an organometallic reaction where ligands are transferred from one species to another. In the case of the Suzuki coupling the ligands are transferred from the organoboron species 6 to the palladium(II) complex 4 where the base that was added in the prior step is exchanged with the R1 substituent on the organoboron species to give the new palladium(II) complex 8. The exact mechanism of transmetalation for the Suzuki coupling remains to be discovered. The organoboron compounds do not undergo transmetalation in the absence of base and it is therefore widely believed that the role of the base is to activate the organoboron compound as well as facilitate the formation of R2-Pdll-OtBu from R2-Pdll-X.[12]

Suzuki Coupling Transmetalation

Reductive elimination[edit]

The final step is the reductive elimination step where the palladium(II) complex (8) eliminates the product (9) and regenerates the palladium(0) catalyst(1). Using deuterium labelling, Ridgway et al. have shown the reductive elimination proceeds with retention of stereochemistry.[16]

Suzuki Coupling Reductive Elimination

Advantages[edit]

The advantages of Suzuki coupling over other similar reactions are availability of common boronic acids, mild reaction conditions, and its less toxic nature. Boronic acids are less toxic and safer for the environment than organostannane and organozinc compound. It is easy to remove the inorganic by-products from reaction mixture. Hence, this reaction is beneficial for using relatively cheap and easily prepared reagents. Being able to use water as a solvent[17] makes this reaction more economical, eco-friendly, and capable of using wide variety of water soluble reagents. There are a wide variety of reagents that can be used for the Suzuki coupling, allowing for its use in many different chemical syntheses. There are reaction conditions that allow aryl- or vinyl-boronic acids and aryl- or vinyl-halides. Work has also extended the scope of the reaction to incorporate alkyl bromides.[18] In addition to many different type of halides being possible for the Suzuki coupling reaction, the reaction also works with pseudohalides such as triflates (OTf), as replacements for halides. The relative reactivity for the coupling partner with the halide or pseudohalide is: R2–I > R2–OTf > R2–Br >> R2–Cl. Boronic esters and organotrifluoroborate salts may be used instead of boronic acids. The catalyst can also be a palladium nanomaterial-based catalyst.[19] With a novel organophosphine ligand (SPhos), a catalyst loading of down to 0.001 mol% has been reported:.[20] These advancements and the diverse number of possibilities for coupling partners, bases and solvents is a large reason why the Suzuki coupling is widely used in research and has recently been utilized in industrial processes for chemical synthesis. Recent applications of the Suzuki–Miyaura cross-coupling reaction in organic synthesis have been summarized by Kotha and co-workers.[21]

Application[edit]

Industrial Applications[edit]

The Suzuki coupling reaction has recently been used to synthesize compounds on an industrial scale.[22] The advances made for the Suzuki coupling reaction in the years since its discovery has made the reaction scalable and cost-effective for use in the synthesis of intermediates for pharmaceuticals or fine chemicals.[22] The Suzuki reaction used to be limited in scope due to higher levels of catalyst needed for the reaction. The number of boronic acids available was also limited, however, there is now a library of boronic acids that you can purchase in addition to those that can be synthesized. Replacements for halides were also found, increasing the number of coupling partners for the halide or pseudohalide as well. Scaled up reactions have been carried out in the synthesis of a number of important biological compounds such as CI-1034 which used a triflate and boronic acid coupling partners which was run on an 80 kilogram scale with a 95% yield.[23]

CI-1034 Synthesis Suzuki

Another example is the coupling of 3-pyridylborane and 1-bromo-3-(methylsulfonyl)benzene that formed an intermediate that was used in the synthesis of a potential central nervous system agent. The coupling reaction to form the intermediate was run on to give the product (278 kilograms) in a 92.5% yield.[15][22]

CNS Intermediate Synthesis Suzuki

Synthetic Applications[edit]

The Suzuki coupling has been frequently used in syntheses of complex compounds.[24][25] The Suzuki coupling has been used on a citronellal derivative for the synthesis of caparratriene, a natural product that is highly active against leukemia:[26]

Suzuki coupling capparatriene.tif

Variations[edit]

Metal Catalyst[edit]

There have been variations of the Suzuki coupling reaction developed. Various catalysts have been utilized other than the original palladium catalyst. In recent years the use of a nickel catalyst has been of interest and advances in this area has been summarized in a recent review.[27] The first nickel catalyzed cross-coupling reaction was reported by Miyaura and co-workers in 1996 using aryl chlorides and boronic acids.[28] Even though a higher amount of nickel catalyst was needed for the reaction, around 3-10%, nickel is not considered as expensive or as precious of a metal as palladium. The nickel catalyzed Suzuki coupling reaction also allowed a number of compounds that did not work or worked worse for the palladium catalyzed system than the nickel-catalyzed system.[27] The use of nickel catalysts has allowed for electrophiles that proved challenging for the original Suzuki coupling using palladium, including substrates such as phenols, aryl ethers, esters, phosphates, and fluorides.[27]

Nickel Suzuki 1

Investigation into the nickel catalyzed cross-coupling continued and increased the scope of the reaction after these first examples were shown and the research interest grew. Miyaura and Inada reported in 2000 that an cheaper nickel catalyst could be utilize for the cross-coupling, using triphenylphosphine (PPh3) instead of the more expensive ligands previously used.[29] However, the nickel-catalyzed cross-coupling still required high catalyst loadings (3-10%), required excess ligand (1-5 equivalents) and remained sensitive to air and moisture.[27] Advancements by Han and co-workers have tried to address that problem by developing a method using low amounts of nickel catalyst (<1 mol%) and no additional equivalents of ligand.[30]

Nickel Suzuki 2

It was also reported by Wu and co-workers in 2011 that a highly active nickel catalyst for the cross-coupling of aryl chlorides could be used that only required 0.01-0.1 mol% of nickel catalyst. They also showed that the catalyst could be recycled up to six times with virtually no loss in catalytic activity.[31] The catalyst was recyclability because it was a phosphine nickel nanoparticle catalyst (G3DenP-Ni) that was made from dendrimers.

Nickel Suzuki 3

There are many advantages and disadvantages for both the palladium and nickel-catalyzed Suzuki coupling reactions. Apart from Pd and Ni catalyst system, cheap and non-toxic metal sources like iron and copper[32] have been used in Suzuki coupling reaction. The Bedford research group[33] and the Nakamura research group[34] have extensively worked on developing the methodology of iron catalyzed Suzuki coupling reaction. Ruthenium is another metal source that has been used in Suzuki coupling reaction.[35]

Organoboranes[edit]

Aryl boronic acids are comparatively cheaper than other organoboranes and a wide variety of aryl boronic acids are commercially available. Hence, it has been widely used in Suzuki reaction as an organoborane partner. Aryltrifluoroborate salts are another class of organoboranes that are frequently used because they are less prone to protodeboronation compared to aryl boronic acids. They are easy to synthesize and can be easily purified.[36] Aryltrifluoroborate salts can be formed from boronic acids by the treatment with potassium hydrogen fluoride which can then be used in the Suzuki coupling reaction.[37]

Variations Suzuki 1
Variations Suzuki 1

Other variations[edit]

Suzuki coupling reaction is different than other coupling reactions regarding the fact that this reaction can be run in biphasic(aqueous and organic)[38] or only in aqueous environments rather than just an organic solvent.[17] This increased the scope of coupling reaction. Variety of water soluble bases, catalyst systems, and reagents can be used without the concern of solubility in organic solvent system. Water, as a solvent system, is also attractive because of the economy and safety. Frequently used solvent system includes toluene,[39] THF,[40] dioxane,[40] and dimethylformamide[41] but are not limited to these. Additionally, a wide variety of bases are implemented in Suzuki coupling reaction. Most frequently used bases are K2CO3,[38] KOtBu,[42] Cs2CO3,[43] K3PO4,[44] NaOH,[45] NEt3.[46]

See also[edit]

References[edit]

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  2. ^ Miyaura, Norio; Suzuki, Akira (1979). "Stereoselective synthesis of arylated (E)-alkenes by the reaction of alk-1-enylboranes with aryl halides in the presence of palladium catalyst". Chem. Comm. (19): 866–867. doi:10.1039/C39790000866. 
  3. ^ Miyaura, Norio; Suzuki, Akira (1995). "Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds". Chemical Reviews 95 (7): 2457–2483. doi:10.1021/cr00039a007. 
  4. ^ Nobelprize.org. "The Nobel Prize in Chemistry 2010". Nobel Prize Foundation. Retrieved 2013-10-25. 
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  6. ^ Miyaura, Norio; Suzuki, Akira (1979). "Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds". Chemical reviews 95 (7): 2457–2483. doi:10.1021/cr00039a007. (Review)
  7. ^ Suzuki, Akira (1999). "Recent advances in the cross-coupling reactions of organoboron derivatives with organic electrophiles, 1995–1998". Journal of Organometallic Chemistry 576: 147. doi:10.1016/S0022-328X(98)01055-9. 
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