Macroglossia
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| Macroglossia | |
|---|---|
| Classification and external resources | |
| ICD-10 | Q38.2 |
| ICD-9 | 529.8 |
| OMIM | 153630 |
| DiseasesDB | 7689 |
| eMedicine | ent/746 |
| MeSH | D008260 |
Macroglossia is the medical term for unusual enlargement (hypertrophy) of the tongue. Severe enlargement of the tongue can cause cosmetic and functional difficulties including in speaking, eating, swallowing and sleeping.
Contents |
[edit] Causes
[edit] Amyloid Disorders
Amyloidosis is an accumulation of insoluble proteins in tissues that impedes normal function.[1]
- 1. Primary amyloidosis
- 2. Myeloma associated amyloidosis[2]
- 3. Lubarsch Pick syndrome [3]
- 4. Immunoglobulinemic amyloidosis
[edit] Hypothyroid Macroglossia
Macroglossia is also a clinical feature in Hypothyroid disorders which include
- 1. congenital hypothyroidism,[4].
- 2. Young Simpson syndrome,[5]
- 3. Zadik Barak Levin syndrome,[6]
- 4. Athyreotic cretinism
- 5. Kocher-Debre-Semelaigne syndrome[7]
[edit] Overgrowth Disorders
[edit] Chromosomal disorders
1. Triploid Syndrome
2. Chromosome 4,trisomy 4p
3. Trisomy 21 (Downs Syndrome)
[edit] Other Miscellaneous
1. Mucopolysaccharidosis[10]
2. MANNOSIDOSIS, ALPHA B, LYSOSOMAL[11]
3. Glycogen storage disease type 2, or Pompe's disease.[12]
4. Fucosidosis
Apparent macroglossia can also occur in Down syndrome.[13]
[edit] References
- ^ Merck Manual 17th Ed.
- ^ http://sciencelinks.jp/j-east/article/200318/000020031803A0392321.php
- ^ http://en.wikipedia.org/wiki/Ludwig_Pick
- ^ Grant DB, Smith I, Fuggle PW, Tokar S, Chapple J (January 1992). "Congenital hypothyroidism detected by neonatal screening: relationship between biochemical severity and early clinical features". Arch. Dis. Child. 67 (1): 87–90. doi:10.1136/adc.67.1.87. PMC 1793539. PMID 1739345. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1793539.
- ^ http://sciencelinks.jp/j-east/article/200223/000020022302A0895118.php
- ^ http://en.wikipedia.org/wiki/Zadik_Barak_Levin_syndrome
- ^ http://www.springerlink.com/content/lh807890491x17h3/
- ^ http://www.joms.org/article/S0278-2391(00)69867-1/abstract
- ^ http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=312870
- ^ http://ghr.nlm.nih.gov/condition=mucopolysaccharidosistypei
- ^ http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=248500
- ^ http://moon.ouhsc.edu/kfung/jty1/neurohelp/ZNN0IE23.htm
- ^ Guimaraes CV, Donnelly LF, Shott SR, Amin RS, Kalra M (October 2008). "Relative rather than absolute macroglossia in patients with Down syndrome: implications for treatment of obstructive sleep apnea". Pediatr Radiol 38 (10): 1062–7. doi:10.1007/s00247-008-0941-7. PMID 18685841.
[edit] External links
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