Syntaxin 3

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Syntaxin 3
Symbols STX3 ; STX3A
External IDs OMIM600876 MGI103077 HomoloGene80191 GeneCards: STX3 Gene
RNA expression pattern
PBB GE STX3 209238 at tn.png
PBB GE STX3 216985 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6809 20908
Ensembl ENSG00000166900 ENSMUSG00000041488
UniProt Q13277 Q64704
RefSeq (mRNA) NM_001178040 NM_001025307
RefSeq (protein) NP_001171511 NP_001020478
Location (UCSC) Chr 11:
59.48 – 59.57 Mb
Chr 19:
11.78 – 11.82 Mb
PubMed search [1] [2]

Syntaxin 3, also known as STX3, is a protein[1] which in humans is encoded by the STX3 gene.[2][3]


The protein encoded by this gene is a member of the syntaxin family of cellular receptors for transport vesicles which participate in exocytosis in neutrophils.[2] STX3 has an important role in the growth of neurites and serves as a direct target for omega-6 arachidonic acid.[4] Mutations in Syntaxin 3 cause Microvillus inclusion disease .Wiegerinck, C. L.; Janecke, A. R.; Schneeberger, K; Vogel, G. F.; Van Haaften-Visser, D. Y.; Escher, J. C.; Adam, R; Thöni, C. E.; Pfaller, K; Jordan, A. J.; Weis, C. A.; Nijman, I. J.; Monroe, G. R.; Van Hasselt, P. M.; Cutz, E; Klumperman, J; Clevers, H; Nieuwenhuis, E. E.; Houwen, R. H.; Van Haaften, G; Hess, M. W.; Huber, L. A.; Stapelbroek, J. M.; Müller, T; Middendorp, S (2014). "Loss of Syntaxin 3 Causes Variant Microvillus Inclusion Disease". Gastroenterology 147 (1): 65–68.e10. doi:10.1053/j.gastro.2014.04.002. PMID 24726755.  edit


Syntaxin 3 has been shown to interact with SNAP-25,[5][6][7] SNAP23[6][7][8][9] and SNAP29.[7]


  1. ^ Ibaraki K, Horikawa HP, Morita T, Mori H, Sakimura K, Mishina M, Saisu H, Abe T (June 1995). "Identification of four different forms of syntaxin 3". Biochem. Biophys. Res. Commun. 211 (3): 997–1005. doi:10.1006/bbrc.1995.1910. PMID 7598732. 
  2. ^ a b Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F (March 1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". J. Leukoc. Biol. 65 (3): 397–406. PMID 10080545. 
  3. ^ "Entrez Gene: STX3 syntaxin 3". 
  4. ^ Darios F, Davletov B (April 2006). "Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3". Nature 440 (7085): 813–7. Bibcode:2006Natur.440..813D. doi:10.1038/nature04598. PMID 16598260. 
  5. ^ Hata, Y; Südhof T C (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. (UNITED STATES) 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. ISSN 0021-9258. PMID 7768895. 
  6. ^ a b Ravichandran, V; Chawla A; Roche P A (Jun 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". J. Biol. Chem. (UNITED STATES) 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. ISSN 0021-9258. PMID 8663154. 
  7. ^ a b c Steegmaier, M; Yang B; Yoo J S; Huang B; Shen M; Yu S; Luo Y; Scheller R H (Dec 1998). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. (UNITED STATES) 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. ISSN 0021-9258. PMID 9852078. 
  8. ^ Imai, Akane; Nashida Tomoko; Yoshie Sumio; Shimomura Hiromi (Aug 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. (England) 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. ISSN 0003-9969. PMID 12828989. 
  9. ^ Araki, S; Tamori Y; Kawanishi M; Shinoda H; Masugi J; Mori H; Niki T; Okazawa H; Kubota T; Kasuga M (May 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochem. Biophys. Res. Commun. (UNITED STATES) 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. ISSN 0006-291X. PMID 9168999. 

Further reading[edit]