Synthetic cannabis is a psychoactive designer drug derived from natural herbs sprayed with synthetic chemicals that, when consumed, allegedly mimic the effects of cannabis. It is best known by the brand names K2 and Spice, both of which have largely become genericized trademarks used to refer to any synthetic cannabis product. (It is also for this reason that synthetic cannabis is often referred to as spice product, due to the latter.) There is controversy among calling Spice and K2 synthetic cannabis and is considered by some to be a misnomer, because the ingredients contained in these products are mimics, not copies of THC.
Research on the safety of synthetic cannabis is only now becoming available. Initial studies are focused on the role of synthetic cannabis and psychosis. It seems likely that synthetic cannabis can precipitate psychosis and in some cases it is prolonged. These studies suggest that synthetic cannabinoid intoxication is associated with acute psychosis, worsening of previously stable psychotic disorders, and also may have the ability to trigger a chronic (long-term) psychotic disorder among vulnerable individuals such as those with a family history of mental illness.
When synthetic cannabis blends first went on sale in the early 2000s (decade), it was thought that they achieved an effect through a mixture of legal herbs. Laboratory analysis in 2008 showed that this is not the case, and that they in fact contain synthetic cannabinoids that act on the body in a similar way to cannabinoids naturally found in cannabis, such as THC. A large and complex variety of synthetic cannabinoids, most often cannabicyclohexanol, JWH-018, JWH-073, or HU-210, are used in an attempt to avoid the laws that make cannabis illegal, making synthetic cannabis a designer drug. It has been sold under various brand names, online, in head shops, and at some gas stations.
It is often marketed as "herbal incense"; however, some brands market their products as "herbal smoking blends". In either case, the products are usually smoked by users. Although synthetic cannabis does not produce positive results in drug tests for cannabis, it is possible to detect its metabolites in human urine. The synthetic cannabinoids contained in synthetic cannabis products have been made illegal in many European countries. On November 24, 2010, the U.S. Drug Enforcement Administration announced it would use emergency powers to ban many synthetic cannabinoids within a month. Prior to the announcement, several US states had already made them illegal under state law. In the US, as of March 1, 2011, five cannabinoids, JWH-018, JWH-073, CP-47,497, JWH-200, and cannabicyclohexanol have been placed on Schedule I of the Controlled Substances Act (and are therefore illegal to possess or use in the US); the Drug Enforcement Administration claims that said action is "to avoid an imminent hazard to the public safety." In July 2012, the Synthetic Drug Abuse Prevention Act of 2012 was signed into law. It banned synthetic compounds commonly found in synthetic marijuana, placing them under Schedule I of the Controlled Substances Act.
According to the Psychonaut Web Mapping Research Project, synthetic cannabis products, sold under the brand name Spice, first appeared in Europe in 2004. The brand "Spice" was released in 2004 by the now-dormant company The Psyche Deli in London, UK. In 2006 the brand gained popularity. According to the Financial Times, the assets of The Psyche Deli rose from £65,000 in 2006 to £899,000 in 2007. The EMCDDA reported in 2009 that 'Spice' products were identified in 21 of the 30 participating countries. Because 'Spice' was the dominant brand until 2009, the competing brands that started to appear from 2008 on were also dubbed 'Spice'. Spice can, therefore, refer to both the brand 'Spice', as to all herbal blends with synthetic cannabinoids added.
In addition to K2 and Spice, other street names include Black Mamba (Turnera diffusa), Bombay Blue, Fake Weed, Genie, and Zohai. According to Partnership at Drugfree.org, other names also include Bliss, Blaze, JWH -018, -073, -250, Yucatan Fire, Skunk and Moon Rocks.
Synthetic cannabis is claimed by the manufacturers to contain a mixture of traditionally used medicinal herbs, each of which producing mild effects, with the overall blend resulting in the cannabis-like intoxication produced by the product. Herbs listed on the packaging of Spice include Canavalia maritima, Nymphaea caerulea, Scutellaria nana, Pedicularis densiflora, Leonotis leonurus, Zornia latifolia, Nelumbo nucifera, and Leonurus sibiricus. However, when the product was analyzed by laboratories in Germany and elsewhere, it was found that many of the characteristic "fingerprint" molecules expected to be present from the claimed plant ingredients were not present. There were also large amounts of synthetic tocopherol present. This suggested that the actual ingredients might not be the same as those listed on the packet, and a German government risk assessment of the product conducted in November 2008 concluded that it was unclear as to what the actual plant ingredients were, where the synthetic tocopherol had come from, and whether the subjective cannabis-like effects were actually produced by any of the claimed plant ingredients or instead caused by a synthetic cannabinoid drug.
Synthetic cannabinoid ingredients
In January 2009, researchers at the University of Freiburg in Germany announced that an active substance in Spice was an undisclosed analogue of the synthetic cannabinoid CP 47,497. Later that month, CP 47,497 along with its dimethylhexyl, dimethyloctyl and dimethylnonyl homologues, were added to the German controlled drug schedules. In May the analogue of CP 47,497 was named cannabicyclohexanol.
In July 2010, it was announced that JWH-018 is one of the active components in at least three versions of Spice, which had been sold in a number of countries around the world since 2002, often marketed as incense. Another potent synthetic cannabinoid, HU-210, has been reported to have been found in Spice seized by U.S. Customs and Border Protection. An analysis of samples acquired four weeks after the German prohibition of JWH-018 took place found that the compound had been replaced with JWH-073.
Different ratios of JWH-018 and CP 47,497 and their analogues have been found in different brands of synthetic cannabis and manufacturers constantly change the composition of their products. The amount of JWH-018 in Spice has been found to vary from 0.2% to 3%.
An analysis of 41 different synthetic cannabis blends sold commercially in New Zealand, conducted by the Institute of Environmental Science and Research and released in July 2011, found 11 different synthetic cannabinoid ingredients used: including JWH-018, JWH-073, AM-694, AM-2201, RCS-4, RCS-4 butyl homologue, JWH-210, JWH-081, JWH-250 (or possibly JWH-302, isomer not determined), JWH-203, and JWH-122—with between one and five different active ingredients, though JWH-018 was present in 37 of the 41 blends tested. In two brands the benzodiazepine anxiolytic drug phenazepam was also found, which is classified as a prescription medicine in New Zealand, and so these brands were ordered to be removed from the market by emergency recall. Since this time, a further 15 cannabinoid compounds have been detected as ingredients of synthetic cannabis blends in New Zealand and banned as temporary class drugs. In 2013 another hypnotic medication, zaleplon was found to have been used as an active ingredient in a blend that had been sold in New Zealand during 2011-2012. Other non-cannabinoid ingredients have also been found in synthetic cannabis blends around the world including substituted cathinone derived stimulant drugs such as 4-methylbuphedrone and 4-methyl-alpha-PPP, and psychedelic tryptamine derivatives such as 4-HO-DET. In 2013 a designer opioid drug AH-7921 was detected in smoking blends in Japan, along with several novel cannabinoids and a cathinone analogue.
|Name||Structure||Binding affinity for the CB1 receptor||Binding affinity for the CB2 receptor|
|THC||Ki = 40.7±1.7 nM||Ki = 36.4±10 nM|
|HU-210||Ki = 234 pM (100–800 times more potent)|
|Cannabicyclohexanol||Ki = unknown. Reported to be 5 times more potent than THC, based on physiological responses in rats|
|JWH-073||Ki = 8.90±1.80 nM||Ki = 38.0±24.0 nM|
|JWH-018||Ki = 9.00±5.00 nM||Ki = 2.94±2.65 nM|
|AM-2201||Ki = 1.0 nM||Ki = 2.6 nM|
No official studies have been conducted on its effects on humans. Though its effects are not well-documented, extremely large doses may cause negative effects that are in general not noted in cannabis users, such as increased agitation and vomiting. Professor John W. Huffman, who first synthesised many of the cannabinoids used in synthetic cannabis, is quoted as saying, "People who use it are idiots." "You don't know what it's going to do to you." A user who consumed 3 g of Spice Gold every day for several months showed withdrawal symptoms, similar to those associated with withdrawing from the use of narcotics. Doctors treating the user also noted that his use of the product showed signs associated with addiction. One case has been reported wherein a user, who had previously suffered from cannabis-induced recurrent psychotic episodes, suffered reactivation of his symptoms after using Spice. Psychiatrists treating him have suggested that the lack of an antipsychotic chemical, similar to cannabidiol found in natural cannabis, may make synthetic cannabis more likely to induce psychosis than natural cannabis.
Studies are currently available which suggest an association between synthetic cannabinoids and psychosis. Physicians should be aware that the use of synthetic cannabinoids can be associated with psychosis and investigate possible use of synthetic cannabinoids in patients with inexplicable psychotic symptoms. Also, people with risk factors for psychosis should be counseled against using synthetic cannabinoids.
Spice does not cause a positive drug test for cannabis or other illegal drugs using GC-MS-screening with library search, multi-target screening by LC-MS/MS, or immunological screening procedures. A study has been conducted into the detection of metabolites of JWH-018 in urine; the metabolites are mainly conjugates with glucuronic acid and can be reliably detected by GC–MS/MS and LC–MS/MS.
- The Austrian Ministry of Health announced on December 18, 2008 that Spice would be controlled under Paragraph 78 of their drug law on the grounds that it contains an active substance that affects the functions of the body, and the legality of JWH-018 is under review.
- JWH-018, CP 47,497 and the C6, C8 and C9 homologues of CP 47,497 are illegal in Germany since January 22, 2009.
- Spice blends are classified as a medicine in Finland, and, therefore, it is illegal to order them without a prescription. In practice, it is not possible to get a prescription.
- JWH-018, CP 47,497 (and its homologues) and HU-210 were all made illegal in France on February 24, 2009.
- From June 2010, JWH-018, along with a variety of other designer drugs, is illegal.
- JWH-018, JWH-073, CP 47,497 (and its homologues) and HU-210 are all banned in Latvia as well as leonotis leonurus.
- JWH-018 and many of the herbs mentioned on the ingredient lists of Spice and similar preparations were made illegal in May 2009. The bill was passed by Polish Sejm, Polish Senat and was signed by the President.
- Spice was made illegal in Romania on February 15, 2010.
- On April 9, 2009, the Chief Medical Officer of the Russian Federation issued a resolution on reinforcing control over the sales of smoking blends. These blends, marketed under the trade names AM-HI-CO, Dream, Spice (Gold, Diamond), Zoom, Ex-ses, Yucatán Fire and others, have been declared to contain Salvia divinorum, Hawaiian Wood Rose, and Blue Lotus, and are prohibited to be sold. These substances have been found to have "psychotropic, narcotic effects, contain poisonous components and represent potential threat for humans". The resolution does not mention JWH-018 or other synthetic cannabinoids. On January 14, 2010, the Russian government issued a statement including 23 synthetic cannabinoids found in smoking blends Hawaiian Rose and Blue Lotus on the list of prohibited narcotic and psychotropic substances. Thus, all of these plants and compounds are now illegal in the Russian Federation.
- Spice is legal in Slovakia. The National Anti-Drug Unit is considering adding it to the list of controlled substances. The latest anti-drug law version (468/2009) valid since January 2010 still does not mention active compounds of Spice.
- CP 47,497-C6, CP 47,497-C7, CP 47,497-C8, CP 47,497-C9, JWH-018, JWH-073 and HU-210 were all made illegal in Sweden on September 15, 2009. The bill was accepted on July 30, 2009 and was put in effect on September 15, 2009.
- Spice has been banned in Switzerland.
- United Kingdom
- Spice was legal in the United Kingdom until December 2009, when it was classified as a Class B drug.
- The Chilean Ministry of Health on April 24, 2009 declared the sale of synthetic cannabis to be illegal.
- South Korea
- South Korea officially added JWH-018, CP 47,497 and HU-210 to the controlled substance list on July 1, 2009, effectively making these chemicals illegal.
- Japan has banned JWH-018, CP 47, 497, and homologues, and HU-210 since October 2009
- United Arab Emirates
- The United Arab Emirates had stated that Spice was an illegal substance and possession or intent to sell would be a jailable offense.
- A variety of synthetic cannabis called Kronic is available in Australia and, As of 15 June 2011[update], is not illegal. However, on June 13, 2011, the Western Australian state government made the decision to place a ban on any products containing synthetic cannabinoids, including brands such as Kronic, Kalma, Voodoo, Kaos, and Mango Kush, effective from Friday the June 17, 2011. This makes Western Australia the first state in Australia to make the synthetic cannabis-containing products illegal. The sale of synthetic cannabis will be banned in the state of NSW from July 1, with retailers required to arrange for destruction of any unsold quantities after that date. A ban on the use of synthetic cannabis will come into effect on the July 8, 2011, under current legislation.
- New Zealand
- Spice is illegal in New Zealand, it is classified as a Class C controlled drug. Kronic is widely available in dairies and is not illegal.[dated info]
The case of David Mitchell Rozga, an American teenager from Indianola, Iowa, United States, brought international attention to K2. Rozga shot himself in the head with a family owned hunting rifle in an apparent suicide in June 6, 2010. After news of Rozga's death, it was reported by friends that they had smoked K2 with Rozga approximately one hour before his death. The nature of his death and reports from numerous family members, had led investigators to believe that it was likely Rozga was under the influence of a mind altering substance, at the time of his death. The death of Rozga has been used as a face of political lobbying against the continuation of K2, and other legal synthetic drugs, such as bath salts.
Following the incident, an act to ban the use and distribution of the drug was proposed by the US Senator Chuck Grassley of Iowa as the David Mitchell Rozga Act. It was approved into legislation by the United States Congress in June 2011,. On July 10, 2012, President Barack Obama signed the Synthetic Drug Abuse Prevention Act of 2012 into law. It banned synthetic compounds commonly found in synthetic marijuana, placing them under Schedule I of the Controlled Substances Act.
Prior to that, some compounds within synthetic cannabis (HU-210) were scheduled in the USA under federal law, while others (JWH-073) have been temporarily scheduled until final determination of their status can be made. The Drug Enforcement Administration (DEA) considers it to be a "drug of concern", citing "...a surge in emergency-room visits and calls to poison-control centers. Adverse health effects associated with its use include seizures, hallucinations, paranoid behavior, agitation, anxiety, nausea, vomiting, racing heartbeat, and elevated blood pressure."
Several states independently passed acts making it illegal under state law, including Kansas in March 2010, Georgia and Alabama in May 2010, Tennessee and Missouri in July 2010, Louisiana in August 2010, Mississippi in September 2010, and Iowa. An emergency order was passed in Arkansas in July 2010 banning the sale of synthetic cannabis. In October 2010, the Oregon Board of Pharmacy listed synthetic cannabinoid chemicals on its Schedule 1 of controlled substance, which means that the sale and possession of these substances is illegal under the Oregon Uniform Controlled Substances Act. According to the National Conference of State Legislatures, several other states are also considering legislation, including Michigan, New Jersey, New York, Florida, Indiana, and Ohio. Illinois passed a law on July 27, 2010 banning all synthetic cannabinoids that goes into effect January 1, 2011. Michigan banned synthetic cannabinoids in October 2010, and the South Dakota Legislature passed a ban on these products which was signed into law by Gov. Dennis Daugaard on February 23, 2012 (and which took immediate effect under an emergency clause of the state constitution). North Carolina banned synthetic cannabis by a unanimous vote of the state senate, due to concerns that its contents and effects are reasonably similar to natural cannabis, and may cause equal effects in terms of psychological dependency.
Following cases in Japan involving the use of synthetic cannabis by Navy, Army and Marine Corps personnel resulted in the official banning of it, a punitive general order issued on January 4, 2010 by the Commander Marine Corps Forces, Pacific prohibits the actual or attempted possession, use, sale, distribution or manufacture of synthetic cannabis as well as any derivative, analogue or variant of it. On June 8, 2010, the U.S. Air Force issued a memorandum that banned the possession and use of Spice, or any other mood-altering substance except alcohol or tobacco, among its service members.
On November 24, 2010, the DEA announced that it would make JWH-018, JWH-073, JWH-200, CP-47,497, and cannabicyclohexanol, which are often found in synthetic cannabis, illegal using emergency powers. They will be placed in Schedule I of the Controlled Substances Act, within a month of the announcement, and the ban will last for at least a year. The temporary ban, for at least a year, came in to effect on March 1, 2011.
On October 20, 2011, the Louisiana State University football program announced that it had suspended three players, including star cornerback Tyrann Mathieu, who tested positive for synthetic cannabis.
- Mary Carmichael (March 4, 2010). "K2: Scary Drug or Another Drug Scare?". Newsweek. Retrieved November 24, 2010.
- "What's the buzz?: Synthetic marijuana, K2, Spice, JWH-018 : Terra Sigillata". Scienceblogs.com. Retrieved November 24, 2010.
- Roland Macher; Tod W. Burke, Ph.D, Stephen S. Owen, Ph.D. "Synthetic Marijuana". FBI Law Enforcement Bulletin. Retrieved 22 July 2012.
- Cannabis, synthetic cannabinoids, and psychosis risk: What the evidence says
- Synthetic Cannabis May Pose an Even Greater Psychosis Risk
- Grim, Ryan (November 24, 2010). "K2 Crackdown: DEA Using Emergency Powers To Ban Fake Pot". The Huffington Post. Retrieved November 25, 2010.
- Jeanne Meserve (February 28, 2011). "DEA imposes "emergency" ban to control synthetic marijuana". CNN.
- Citing Imminent Hazard to Public Safety, DEA Temporarily Places Synthetic Cannabinoids Into Schedule I
- Vashi, Sonam (September 26, 2012). K2 Trend Not Slowing Down WebMD Medical News via KOKI-TV
- Spice Report Psychonaut Web Mapping Research Project
- "The story of Spice". Financial Times. February 13, 2009. Retrieved September 19, 2010.
- Winstock, A.; Mitcheson, L.; Deluca, P.; Davey, Z.; Corazza, O.; Schifano, F. (2010). "Mephedrone, new kid for the chop?". Addiction (Abingdon, England) 106 (1): 154–161. doi:10.1111/j.1360-0443.2010.03130.x. PMID 20735367.
- K2 – Spice via Partnership at Drugfree.org
- 19, 2009.19/ Hauptwirkstoff von "Spice Girl" identifiziert. W was here. January 19, 2009 (German)
- "Modedroge "Spice" ist verboten!" (in German). Bmg.bund.de. March 10, 2009. Retrieved August 24, 2010.
- BGBl I Nr. 3 vom January 21, 2009, 22. BtMÄndV vom 19. Jan 2009, S. 49–50.
- Uchiyama N, Kikura-Hanajiri R, Ogata J, Goda Y (May 2010). "Chemical analysis of synthetic cannabinoids as designer drugs in herbal products". Forensic Science International 198 (1–3): 31–8. doi:10.1016/j.forsciint.2010.01.004. PMID 20117892.
- "Gefährlicher Kick mit Spice (German)". Fr-online.de. Retrieved August 24, 2010.
- "Erstmals Bestandteile der Modedroge "Spice" nachgewiesen (German)". Haz.de. Retrieved August 24, 2010.
- "Spice enthält chemischen Wirkstoff (German)". Badische-zeitung.de. Retrieved August 24, 2010.
- Schifano, F.; Corazza, O.; Deluca, P.; Davey, Z.; Di Furia, L.; Farre', M.; Flesland, L.; Mannonen, M. et al. (2009). "Psychoactive drug or mystical incense? Overview of the online available information on Spice products". International Journal of Culture and Mental Health 2: 137. doi:10.1080/17542860903350888.
- "Spice" – Plant material(s) laced with synthetic cannabinoids or cannabinoid mimicking compounds (U.S. Drug Enforcement Administration)
- Lindigkeit, Rainer; Boehme, A; Eiserloh, I; Luebbecke, M; Wiggermann, M; Ernst, L; Beuerle, T (October 30, 2009). "Spice: A never-ending story?". Forensic Science International 191 (1): 58–63. doi:10.1016/j.forsciint.2009.06.008. PMID 19589652
- Auwärter, V., et al. (2009). "'Spice' and other herbal blends: harmless incense or cannabinoid designer drugs?". Journal of mass spectrometry : JMS 44 (5): 832–837. doi:10.1002/jms.1558. PMID 19189348. Free version
- Emanuel, C. E. J.; Ellison, B.; Banks, C. E. (2010). "Spice up your life: screening the illegal components of ‘Spice’ herbal products". Analytical Methods 2 (6): 614. doi:10.1039/c0ay00200c.
- Stafford, Ned. Synthetic Cannabis Mimic Found in Herbal Incense. Royal Society of Chemistry: Chemistry World. January 15, 2009. Accessed: June 17, 2010
- Whitworth, Chris (July 7, 2011). "Kronic ingredients secret to stop industry 'cowboys'". 3 News. Retrieved November 16, 2011.
- 'Herbal High' synthetic Cannabinoid composition, released by ESR July 2011. (PDF) . Retrieved on August 7, 2011.
- Temporary Class Drug Notices. New Zealand Ministry of Health
- Conviction for sale of herbal smoking material containing a prescription medicine. MedSafe Media release, 28 March 2013
- Kikura-Hanajiri, R.; Uchiyama, N.; Goda, Y. (2011). "Survey of current trends in the abuse of psychotropic substances and plants in Japan". Legal Medicine 13 (3): 109–115. doi:10.1016/j.legalmed.2011.02.003. PMID 21377397.
- Uchiyama, N.; Kawamura, M.; Kikura-Hanajiri, R.; Goda, Y. (2012). "URB-754: A new class of designer drug and 12 synthetic cannabinoids detected in illegal products". Forensic Science International 227 (1–3): 21–32. doi:10.1016/j.forsciint.2012.08.047. PMID 23063179.
- Uchiyama, N.; Matsuda, S.; Kawamura, M.; Kikura-Hanajiri, R.; Goda, Y. (2013). "Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products". Forensic Toxicology. doi:10.1007/s11419-013-0182-9.
- Aung, M. M.; Griffin, G.; Huffman, J. W.; Wu, M. J.; Keel, C.; Yang, B.; Showalter, V. M.; Abood, M. E. et al. (2000). "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding". Drug and Alcohol Dependence 60 (2): 133–140. doi:10.1016/S0376-8716(99)00152-0. PMID 10940540.
- Devane, W. A., et al. (1992). "A novel probe for the cannabinoid receptor". Journal of Medical Chemistry 35 (11): 2065–2069. doi:10.1021/jm00089a018. PMID 1317925.
- Compton, D.; Johnson, M.; Melvin, L.; Martin, B. (1992). "Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents". The Journal of Pharmacology and Experimental Therapeutics 260 (1): 201–209. PMID 1309872.
- WO patent 200128557, Makriyannis A, Deng H, "Cannabimimetic indole derivatives", granted June 7, 2001
- "Fake pot that acts real stymies law enforcement". Associated Press. February 17, 2010. Retrieved April 21, 2010.
- Jeanna Bryner (March 3, 2010). "Fake Weed, Real Drug: K2 Causing hallucinations in Teens". LiveScience. Retrieved April 21, 2010.
- "Fake Weed, Real Drug: K2 Causing Hallucinations in Teens". LiveScience. Retrieved November 24, 2010.
- Zimmermann, U., et al. (2009). "Withdrawal phenomena and dependence syndrome after the consumption of "spice gold"". Deutsches Arzteblatt international 106 (27): 464–467. doi:10.3238/arztebl.2009.0464. PMC 2719097. PMID 19652769.
- Müller, H.; Sperling, W.; Köhrmann, M.; Huttner, H.; Kornhuber, J.; Maler, J. (2010). "The synthetic cannabinoid Spice as a trigger for an acute exacerbation of cannabis induced recurrent psychotic episodes". Schizophrenia research 118 (1–3): 309–310. doi:10.1016/j.schres.2009.12.001. PMID 20056392.
- Hurst, D; Loeffler, G, McLay, R (2011 Oct). "Psychosis associated with synthetic cannabinoid agonists: a case series.". The American Journal of Psychiatry 168 (10): 1119. doi:10.1176/appi.ajp.2011.11010176. PMID 21969050.
- Every-Palmer, S (2011 September 1). "Synthetic cannabinoid JWH-018 and psychosis: an explorative study.". Drug and alcohol dependence 117 (2-3): 152–7. doi:10.1016/j.drugalcdep.2011.01.012. PMID 21316162.
- Mir, A; Obafemi, A, Young, A, Kane, C (2011 Dec). "Myocardial infarction associated with use of the synthetic cannabinoid k2.". Pediatrics 128 (6): e1622–7. doi:10.1542/peds.2010-3823. PMID 22065271.
- Schneir, AB; Baumbacher, T (2011 December 13). "Convulsions Associated with the Use of a Synthetic Cannabinoid Product.". Journal of medical toxicology : official journal of the American College of Medical Toxicology 8 (1): 62–4. doi:10.1007/s13181-011-0182-2. PMID 22160733.
- Sobolevsky, T.; Prasolov, I.; Rodchenkov, G. (2010). "Detection of JWH-018 metabolites in smoking mixture post-administration urine". Forensic Science International 200 (1–3): 141–147. doi:10.1016/j.forsciint.2010.04.003. PMID 20430547.
- "Kräutermischung "Spice": Gesundheitsministerium stoppt Handel, December 18, 2008". Derstandard.at. December 19, 2008. Retrieved June 19, 2010.
- (AFP) (December 18, 2008). "Austria bans herbal incense 'Spice'". Google. Retrieved June 19, 2010.
- "Gesundheitsministerium setzt Maßnahme zum Verbot von "Spice"". Bmgfj.gv.at. December 18, 2008. Retrieved June 19, 2010.
- "Betäubungsmittelrecht: Modedroge Spice wird per Eilverordnung verboten". Der Spiegel. Retrieved June 19, 2010.
- "Arrêté du 24 février 2009 modifiant l’arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants". Journal Officiel De La République Française. February 27, 2009. Retrieved June 19, 2010.
- "Move on head shops 'not enough' – The Irish Times — Wed, Mar 3, 2010". The Irish Times. March 3, 2010. Retrieved August 24, 2010.
- "Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem". Likumi.lv. Retrieved June 19, 2010.
- mm, PAP (February 12, 2009). "Sejm za delegalizacją 'dopalaczy'". Wiadomosci.gazeta.pl. Retrieved June 19, 2010.
- "Senat poparł ustawę zakazującą handlu "dopalaczami" – Wiadomości — WP.PL". Wiadomosci.wp.pl. Retrieved June 19, 2010.
- "OUG 6/2010 pentru modificarea si completarea Legii nr. 143/2000 privind prevenirea si combaterea traficului si consumului ilicit de droguri si pentru completarea Legii nr. 339/2005 privind regimul juridic al plantelor, substantelor si preparatelor stupefiante si psihotrope. Ordonanta de urgenta nr. 6/2010". Dreptonline.ro. August 3, 2000. Retrieved June 19, 2010.
- "О запрещении реализации продукции с содержанием шалфея предсказателей, гавайской розы и голубого лотоса". Rospotrebnadzor.ru. Retrieved June 19, 2010.
- "Постановление от 31 декабря 2009 г. № 1186 О внесении изменений в некоторые постановления Правительства Российской Федерации по вопросам, связанным с оборотом наркотических средств". Government.ru. Retrieved June 19, 2010.
- "Po ketamíne by sa mala zakázať bylinná zmes Spice". SME.sk. Retrieved June 19, 2010.
- [dead link]
- "Regeringen förbjuder nätdrogen "Spice" from the website of the Government Offices of Sweden". Regeringen.se. Retrieved June 19, 2010.
- Adams, Stephen (February 13, 2009). "Teens in Britain getting legally high on synthetic cannabis banned across Europe". The Daily Telegraph (UK). Retrieved August 13, 2009.
- Portal, Gaetan (December 23, 2009). "'Legal high' drugs banned in UK". BBC News. Retrieved May 23, 2010.
- "Chile prohibe uso de spice, La Nacion 24 de Abril 2009". Lanacion.cl. Retrieved June 19, 2010.
- 최연희 (July 2, 2009). "1일부터 '5-메오-밉트’ 등 향정신성의약품 지정" (in Korean). 헬스코리아뉴스. Retrieved February 18, 2010.
- Dubai Customs foil 126 attempts to smuggle narcotic
- "Spice now listed as Schedule 1 drug, AF has ability to test". April 20, 2011. Retrieved April 28, 2011.
- O'Brien, Amanda (April 11, 2011). "Miners working high on synthetic grass". The Australian. Retrieved April 17, 2011.
- Jerga, Josh (June 13, 2011). "Fake cannabis to be outlawed in WA". The Sydney Morning Herald. Retrieved June 15, 2011.
- Dunning, Craig (June 28, 2011). "NSW to ban synthetic cannabis Kronic". The Daily Telegraph. Retrieved June 28, 2011.
- "Cannabis substitute "Spice" now illegal". TVNZ. April 1, 2009. Retrieved March 2, 2011.
- McNeilly, Hamish (June 10, 2011). "Judge shops for synthetic cannabis". The New Zealand Herald. Retrieved June 10, 2011.
- "Controlled Drugs and Substances Act". Laws.justice.gc.ca. November 15, 2010. Retrieved November 24, 2010.
- "Consolidated Index of Drugs and Substances". Isomerdesign.com. April 24, 2010. Retrieved June 19, 2010.
- "Ian Bussières : Le spice: la capitale craque pour les "herbes magiques" | Société". Cyberpresse.ca. Retrieved June 19, 2010.
- "Une pilule une petite granule : Le Spice, un substitut au cannabis ?". Pilule.telequebec.tv. Retrieved June 19, 2010.
- "K2 Drug Facts". K2drugfacts.com. Retrieved 2012-09-09.
- "The David Mitchell Rozga Act (S.605 - Dangerous Synthetic Drug Control Act of 2011)". Opencongress.org. Retrieved 2012-09-09.
- "HU-210". USDOJ.gov. Retrieved September 16, 2010.
- Cook, Morgan (February 28, 2011). "Synthetic marijuana illegal as of Tuesday". North County Times (San Diego). Retrieved February 28, 2011.
- [dead link]
- "Drug Scheduling from the US Drug Enforcement Administration website". Justice.gov. Retrieved June 19, 2010.
- Donna Leinwand (May 24, 2010). 24, 2010-k2_N.htm "Places race to outlaw K2 'Spice' drug". USA Today. Retrieved July 26, 2010.
- Meserve, Jeanne (February 28, 2011). "DEA imposes "emergency" ban to control synthetic marijuana". CNN. Retrieved March 1, 2011.
- Ben Paynter: The Big Business of Synthetic Highs, Bloomerg Businessweek June, 2011
- The Associated Press. How major issues fared in Kansas Legislature. CNBC. May 23, 2010. Accessed: May 23, 2010
- Simmons, Andria (May 24, 2010). "Governor signs bill to outlaw synthetic marijuana". ajc.com. Retrieved June 19, 2010.
- May 20, 2010 (May 20, 2010). "Alabama Coalition Gets Salvia and K2 Banned in Their State". CADCA. Retrieved August 24, 2010.
- Haas, Brian. 'K2', 'K3' synthetic drugs are illegal in TN starting July 1. The Tennessean. May 30, 2010. Accessed: June 17, 2010
- Gay, Malcolm. (2010-07-10) Synthetic Marijuana Spurs State Bans. New York Times. Retrieved on August 7, 2011.
- Iowa Code § 124.204(4)(u) (defining a Schedule I controlled substance to include "synthetic equivalents of the substances contained in the Cannabis plant, or in the resinous extractives of such plant, and synthetic substances, derivatives, and their isomers with similar chemical structure and pharmacological activity to those substances contained in the plant....")
- Gavin Lesnick (July 2, 2010). "Beebe signs emergency ban on K2". Arkansas Online (Arkansas Democrat Gazette). Retrieved July 26, 2010.
- "Synthetic Cannabis — Controlled Substance Information". Retrieved October 16, 2010.
- Daniel Martynowicz. "Illinois Bans Synthetic Cannabinoids". Retrieved September 14, 2010.
- Argus Leader, "New law bans synthetic drugs," by John Hult (February 23rd 2012 - retrieved on May 14th, 2012).
- "NC Senate OKs synthetic pot ban". WRAL-TV. 10 February 2011. Retrieved 27 September 2012.
- "Make Synthetic Cannabinoids Illegal". General Assembly of North Carolina. 31 January 2011. Retrieved 27 September 2012.
- Allan, David; Fisher, Cindy. Ruling Clarifies 'Legal' Drug Policy. Stars and Stripes via Military.com. May 23, 2010. Accessed: May 23, 2010
- Marines Ban Spice Drug. Military.com. May 23, 2010. Accessed: May 23, 2010
- "Air Force officials ban use and possession of spice, mood-altering substances. Air Force News. June 17, 2010. Accessed: June 18, 2010". Af.mil. Retrieved June 19, 2010.
- "DEA Moves to Emergency Control Synthetic Marijuana". DEA Public Affairs. U.S. Drug Enforcement Administration. November 24, 2010. Retrieved February 19, 2011.
- Grim, Ryan (November 24, 2010). "K2 Crackdown: DEA Using Emergency Powers To Ban Fake Pot". Huffington Post. Retrieved November 24, 2010.
- By the CNN Wire Staff (November 24, 2010). "Feds move to ban 'fake pot'". CNN. Retrieved November 24, 2010.
- Meserve, Jeanne (February 28, 2011). "DEA imposes "emergency" ban to control synthetic marijuana". CNN. Retrieved March 1, 2011.
- Schlabach, Mark (October 20, 2011). "Sources: LSU players had positive tests". ESPN.com. Retrieved November 4, 2011.