Having formed in 2010 with the intention of playing in the new I-League (a United Soccer Leagues league set to begin play in 2011), the team moved to the MISL when the two struggling leagues merged. The team was rumored to be named the Syracuse Scorpions and revive the name of an old American Soccer League team. However, the name Silver Knights was announced at the team's inaugural press conference. The club is coached by President, Team Owner and Syracuse native Tommy Tanner. The club has signed former Syracuse Salty Dogs player Ryan Hall, among others. The team announced the signing of former Major League Soccer star Diego Serna on October 11, 2011.
The team finished third in the Eastern Division in 2012, having been eliminated from playoff contention when the Rochester Lancers beat the Wichita Wings on February 23, 2012.
In 2013, the Silver Knight foundation was launched to help benefit kids in tough economic and social situations. The foundation hosts events throughout the year which helps raise money for these children. Many Silver Knights players, including reserve and U19 players, volunteer their time to help partake in the events.
The Silver Knights also have a youth team. Local youth team CNY United was given permission by Tommy Tanner become "Syracuse Silver Knights U19". They are coached by Silver Knights assistant coach Joe Papaleo and Silver Knights first team player LJ Papaleo.