T-type calcium channel
| calcium channel, voltage-dependent, T type, alpha 1G subunit | |
|---|---|
| Identifiers | |
| Symbol | CACNA1G |
| IUPHAR | Cav3.1 |
| HUGO | 1394 |
| OMIM | 604065 |
| RefSeq | NM_018896 |
| UniProt | O43497 |
| Other data | |
| Locus | Chr. 17 q22 |
| calcium channel, voltage-dependent, T type, alpha 1H subunit | |
|---|---|
| Identifiers | |
| Symbol | CACNA1H |
| IUPHAR | Cav3.2 |
| Entrez | 8912 |
| HUGO | 1395 |
| OMIM | 607904 |
| RefSeq | NM_001005407 |
| UniProt | O95180 |
| Other data | |
| Locus | Chr. 16 p13.3 |
| calcium channel, voltage-dependent, T type, alpha 1I subunit | |
|---|---|
| Identifiers | |
| Symbol | CACNA1I |
| IUPHAR | Cav3.3 |
| Entrez | 8911 |
| HUGO | 1396 |
| OMIM | 608230 |
| RefSeq | NM_001003406 |
| UniProt | Q9P0X4 |
| Other data | |
| Locus | Chr. 22 q13.1 |
The T-type calcium channel is a type of voltage-gated calcium channel. "T" stands for transient referring to the length of activation. As with other sub-types of voltage-gated calcium channel, the α1 subunit is the one that determines most of the channel's properties. T-type calcium channels may contain one of three α1 subunits, α1G (Cav3.1), α1H (Cav3.2) or α1I (Cav3.3)[1][2][3].
Along with sodium "funny current," the T-type calcium channel produces the pacemaker potential in the SA node of the heart.[4] Similarly in the CNS, T-type calcium channels and H-type "funny current" cation channels contribute to tonic bursting activity in thalamus. [5] and in low-threshold spikes.
T-type calcium channel blockers are used primarily as antiepileptics.[6]
Pharmacological evidence suggests a role for T-type calcium channels in animal models of pulmonary hypertension. [7]
[edit] See also
[edit] References
- ^ Nilius B, Talavera K, Verkhratsky A (August 2006). "T-type calcium channels: the never ending story". Cell Calcium 40 (2): 81–8. doi:10.1016/j.ceca.2006.04.011. PMID 16797069.
- ^ Perez-Reyes E, Lory P (December 2006). "Molecular biology of T-type calcium channels". CNS Neurol Disord Drug Targets 5 (6): 605–9. doi:10.2174/187152706779025508. PMID 17168745. http://www.bentham-direct.org/pages/content.php?CNSNDDT/2006/00000005/00000006/0004Z.SGM.
- ^ Talavera K, Nilius B (August 2006). "Biophysics and structure-function relationship of T-type Ca2+ channels". Cell Calcium 40 (2): 97–114. doi:10.1016/j.ceca.2006.04.013. PMID 16777221.
- ^ Mangoni ME, Couette B, Marger L, Bourinet E, Striessnig J, Nargeot J (2006). "Voltage-dependent calcium channels and cardiac pacemaker activity: from ionic currents to genes". Prog. Biophys. Mol. Biol. 90 (1–3): 38–63. doi:10.1016/j.pbiomolbio.2005.05.003. PMID 15979127.
- ^ Huguenard JR (1996). "Low-threshold calcium currents in central nervous system neurons". Ann Rev Physio 58: 329–348. doi:10.1146/annurev.ph.58.030196.001553. PMID 8815798.
- ^ Lory P, Chemin J (May 2007). "Towards the discovery of novel T-type calcium channel blockers". Expert Opin. Ther. Targets 11 (5): 717–22. doi:10.1517/14728222.11.5.717. PMID 17465728.
- ^ Paffett ML,; Riddle, M. A.; Kanagy, N. L.; Resta, T. C.; Walker, B. R. (June 2010). "Altered Protein Kinase C Regulation of Pulmonary Endothelial Store- and Receptor-Operated Ca2+ Entry after Chronic Hypoxia". J Pharmacol Exp Ther 54 (7): 46–9. doi:10.1124/jpet.110.165563. PMC 2939669. PMID 20576798. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2939669.
[edit] External links
- MeSH T-Type+Calcium+Channel
- "Voltage-Gated Calcium Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/IC/FamilyMenuForward?familyId=11.
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