TACC1

Transforming, acidic coiled-coil containing protein 1
Identifiers
Symbols	TACC1; DKFZp686K18126; FLJ42304; Ga55; KIAA1103
External IDs	OMIM: 605301 MGI: 2443510 HomoloGene: 4575 GeneCards: TACC1 Gene
Gene Ontology Molecular function • protein binding • protein domain specific binding Cellular component • nucleus • cytoplasm • microtubule organizing center • microtubule cytoskeleton • intermediate filament cytoskeleton Biological process • microtubule cytoskeleton organization • cell cycle • cell proliferation • cerebral cortex development • neurogenesis • interkinetic nuclear migration • regulation of microtubule-based process • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6867	320165
Ensembl	ENSG00000147526	ENSMUSG00000065954
UniProt	O75410	Q6Y685
RefSeq (mRNA)	NM_001122824.1	NM_177089
RefSeq (protein)	NP_001116296.1	NP_796063
Location (UCSC)	Chr 8: 38.59 – 38.71 Mb	Chr 8: 26.27 – 26.31 Mb
PubMed search	[1]	[2]

Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the TACC1 gene.

The function of this gene has not yet been determined; however, it is speculated that it may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers.

Interactions

TACC1 has been shown to interact with Aurora A kinase, TDRD7, SNRPG, Aurora B kinase, LSM7, BARD1 and CKAP5.

Further reading

• Lappin TR, Mullan RN, Stewart JP, et al. (2003). "AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains". Leuk. Lymphoma 43 (7): 1455–9. doi:10.1080/1042819022386644. PMID 12389629. 
• Still IH, Vince P, Cowell JK (1999). "The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines". Genomics 58 (2): 165–70. doi:10.1006/geno.1999.5829. PMID 10366448. 
• Still IH, Hamilton M, Vince P, et al. (1999). "Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon". Oncogene 18 (27): 4032–8. doi:10.1038/sj.onc.1202801. PMID 10435627. 
• Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851. 
• Gergely F, Karlsson C, Still I, et al. (2001). "The TACC domain identifies a family of centrosomal proteins that can interact with microtubules". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14352–7. doi:10.1073/pnas.97.26.14352. PMC 18922. PMID 11121038. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18922. 
• Lauffart B, Howell SJ, Tasch JE, et al. (2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1): 195–200. doi:10.1042/0264-6021:3630195. PMC 1222467. PMID 11903063. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222467. 
• Linē A, Stengrēvics A, Slucka Z, et al. (2002). "Serological identification and expression analysis of gastric cancer-associated genes". Br. J. Cancer 86 (11): 1824–30. doi:10.1038/sj.bjc.6600321. PMC 2375403. PMID 12087473. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2375403. 
• Conte N, Charafe-Jauffret E, Delaval B, et al. (2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene 21 (36): 5619–30. doi:10.1038/sj.onc.1205658. PMID 12165861. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Line A, Slucka Z, Stengrevics A, et al. (2003). "Altered splicing pattern of TACC1 mRNA in gastric cancer". Cancer Genet. Cytogenet. 139 (1): 78–83. doi:10.1016/S0165-4608(02)00607-6. PMID 12547166. 
• Conte N, Delaval B, Ginestier C, et al. (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251. 
• Gangisetty O, Lauffart B, Sondarva GV, et al. (2004). "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases". Oncogene 23 (14): 2559–63. doi:10.1038/sj.onc.1207424. PMID 14767476. 
• Delaval B, Ferrand A, Conte N, et al. (2004). "Aurora B -TACC1 protein complex in cytokinesis". Oncogene 23 (26): 4516–22. doi:10.1038/sj.onc.1207593. PMID 15064709. 
• Still IH, Vettaikkorumakankauv AK, DiMatteo A, Liang P (2004). "Structure-function evolution of the Transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms". BMC Evol. Biol. 4: 16. doi:10.1186/1471-2148-4-16. PMC 441373. PMID 15207008. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=441373. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. 
• Lauffart B, Dimatteo A, Vaughan MM, et al. (2007). "Temporal and spatial expression of TACC1 in the mouse and human". Dev. Dyn. 235 (6): 1638–47. doi:10.1002/dvdy.20724. PMID 16496324. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.