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Tumor-associated calcium signal transducer 2
Symbols TACSTD2 ; EGP-1; EGP1; GA733-1; GA7331; GP50; M1S1; TROP2
External IDs OMIM137290 MGI1861606 HomoloGene1763 GeneCards: TACSTD2 Gene
RNA expression pattern
PBB GE TACSTD2 202286 s at tn.png
PBB GE TACSTD2 202287 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4070 56753
Ensembl ENSG00000184292 ENSMUSG00000051397
UniProt P09758 Q8BGV3
RefSeq (mRNA) NM_002353 NM_020047
RefSeq (protein) NP_002344 NP_064431
Location (UCSC) Chr 1:
59.04 – 59.04 Mb
Chr 6:
67.53 – 67.54 Mb
PubMed search [1] [2]

Tumor-associated calcium signal transducer 2 is a protein that in humans is encoded by the TACSTD2 gene.[1][2][3]

This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.[3]


  1. ^ Linnenbach AJ, Seng BA, Wu S, Robbins S, Scollon M, Pyrc JJ, Druck T, Huebner K (Apr 1993). "Retroposition in a family of carcinoma-associated antigen genes". Mol Cell Biol 13 (3): 1507–15. PMC 359462. PMID 8382772. 
  2. ^ Calabrese G, Crescenzi C, Morizio E, Palka G, Guerra E, Alberti S (Apr 2001). "Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization". Cytogenet Cell Genet 92 (1-2): 164–5. doi:10.1159/000056891. PMID 11306819. 
  3. ^ a b "Entrez Gene: TACSTD2 tumor-associated calcium signal transducer 2". 

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