Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs.
^Jacq X, Brou C, Lutz Y, Davidson I, Chambon P, Tora L (November 1994). "Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor". Cell79 (1): 107–17. doi:10.1016/0092-8674(94)90404-9. PMID7923369.CS1 maint: Date and year (link)
^Ruppert S, Wang EH, Tjian R (March 1993). "Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation". Nature362 (6416): 175–9. doi:10.1038/362175a0. PMID7680771.CS1 maint: Date and year (link)
Parada CA, Yoon JB, Roeder RG (1995). "A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro". J. Biol. Chem.270 (5): 2274–83. doi:10.1074/jbc.270.5.2274. PMID7836461.
Kashanchi F, Piras G, Radonovich MF, Duvall JF, Fattaey A, Chiang CM et al. (1994). "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature367 (6460): 295–9. doi:10.1038/367295a0. PMID8121496.
Scheer E, Mattei MG, Jacq X, Chambon P, Tora L (1995). "Organization and chromosomal localization of the gene (TAF2H) encoding the human TBP-associated factor II 30 (TAFII30)". Genomics29 (1): 269–72. doi:10.1006/geno.1995.1243. PMID8530084.
Wang Z, Morris GF, Rice AP, Xiong W, Morris CB (1996). "Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol.12 (2): 128–38. doi:10.1097/00042560-199606010-00005. PMID8680883.
García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem.272 (11): 6951–8. doi:10.1074/jbc.272.11.6951. PMID9054383.Vancouver style error (help)
Chéhensse V, Boulvin C, Luce S, Tora L, Junien C, Henry I (1997). "Assignment of the human TAFII30 gene (TAF2H) to human chromosome band 11p15.3 using somatic cell hybrids". Cytogenet. Cell Genet.76 (1-2): 41–2. doi:10.1159/000134510. PMID9154123.Vancouver style error (help)
Vassilev A, Yamauchi J, Kotani T, Prives C, Avantaggiati ML, Qin J et al. (1998). "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily". Mol. Cell2 (6): 869–75. doi:10.1016/S1097-2765(00)80301-9. PMID9885574.
Brand M, Yamamoto K, Staub A, Tora L (1999). "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction". J. Biol. Chem.274 (26): 18285–9. doi:10.1074/jbc.274.26.18285. PMID10373431.