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TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
Protein TAF12 PDB 1h3o.png
PDB rendering based on 1h3o.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TAF12 ; TAF2J; TAFII20
External IDs OMIM600773 MGI1913714 HomoloGene68477 GeneCards: TAF12 Gene
RNA expression pattern
PBB GE TAF12 209463 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6883 66464
Ensembl ENSG00000120656 ENSMUSG00000028899
UniProt Q16514 Q8VE65
RefSeq (mRNA) NM_001135218 NM_025579
RefSeq (protein) NP_001128690 NP_079855
Location (UCSC) Chr 1:
28.92 – 28.97 Mb
Chr 4:
132.27 – 132.3 Mb
PubMed search [1] [2]

Transcription initiation factor TFIID subunit 12 is a protein that in humans is encoded by the TAF12 gene.[1][2]

Control of transcription by RNA polymerase II involves the basal transcription machinery, which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes that are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached, whereas others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I.[2]


TAF12 has been shown to interact with TAF9[3] and Transcription initiation protein SPT3 homolog.[3]


Further reading[edit]