TAF15

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TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
Identifiers
Symbols TAF15 ; Npl3; RBP56; TAF2N; TAFII68
External IDs OMIM601574 MGI1917689 HomoloGene131088 GeneCards: TAF15 Gene
RNA expression pattern
PBB GE TAF15 202840 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8148 70439
Ensembl ENSG00000172660 ENSMUSG00000020680
UniProt Q92804 E9Q6D4
RefSeq (mRNA) NM_003487 NM_027427
RefSeq (protein) NP_003478 NP_081703
Location (UCSC) Chr 17:
34.14 – 34.19 Mb
Chr 11:
83.47 – 83.51 Mb
PubMed search [1] [2]

TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene.[1][2][3]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified.[3]

Interactions[edit]

TAF15 has been shown to interact with TAF7,[4] POLR2C,[4] TAF5,[4] POLR2E,[4] TAF13,[4] SAFB,[5] TAF11,[4] TATA binding protein[6] and POLR2G.[4]

References[edit]

  1. ^ Morohoshi F, Arai K, Takahashi EI, Tanigami A, Ohki M (Mar 1997). "Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins". Genomics 38 (1): 51–7. doi:10.1006/geno.1996.0591. PMID 8954779. 
  2. ^ Morohoshi F, Ootsuka Y, Arai K, Ichikawa H, Mitani S, Munakata N, Ohki M (Dec 1998). "Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes". Gene 221 (2): 191–8. doi:10.1016/S0378-1119(98)00463-6. PMID 9795213. 
  3. ^ a b "Entrez Gene: TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa". 
  4. ^ a b c d e f g Bertolotti, A; Melot T, Acker J, Vigneron M, Delattre O, Tora L (Mar 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. (UNITED STATES) 18 (3): 1489–97. ISSN 0270-7306. PMC 108863. PMID 9488465. 
  5. ^ Townson, Steven M; Kang Kaiyan, Lee Adrian V, Oesterreich Steffi (Jun 2004). "Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a potent transcriptional repression domain". J. Biol. Chem. (United States) 279 (25): 26074–81. doi:10.1074/jbc.M313726200. ISSN 0021-9258. PMID 15066997. 
  6. ^ Hoffmann, A; Roeder R G (Jul 1996). "Cloning and characterization of human TAF20/15. Multiple interactions suggest a central role in TFIID complex formation". J. Biol. Chem. (UNITED STATES) 271 (30): 18194–202. doi:10.1074/jbc.271.30.18194. ISSN 0021-9258. PMID 8663456. 

Further reading[edit]