TAF1B

TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
Identifiers
Symbols	TAF1B; MGC:9349; RAF1B; RAFI63; SL1; TAFI63
External IDs	OMIM: 604904 MGI: 109577 HomoloGene: 31331 GeneCards: TAF1B Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity Cellular component • nucleus • nucleoplasm • nucleoplasm Biological process • transcription, DNA-dependent • regulation of transcription, DNA-dependent • transcription from RNA polymerase I promoter • transcription initiation from RNA polymerase I promoter • transcription elongation from RNA polymerase I promoter • termination of RNA polymerase I transcription Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9014	21340
Ensembl	ENSG00000115750	ENSMUSG00000059669
UniProt	Q53T94	n/a
RefSeq (mRNA)	NM_005680	XM_973112
RefSeq (protein)	NP_005671	NP_065639.2
Location (UCSC)	Chr 2: 9.98 – 10.07 Mb	Chr 12: 25.18 – 25.24 Mb
PubMed search	[1]	[2]

TATA box-binding protein-associated factor RNA polymerase I subunit B is an enzyme that in humans is encoded by the TAF1B gene.

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs.

Interactions

TAF1B has been shown to interact with RRN3.

Further reading

• Di Pietro C, Rapisarda A, Amico V et al (2000). "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1". Cytogenet. Cell Genet. 89 (1–2): 133–6. doi:10.1159/000015592. PMID 10894955. 
• Zhai W, Comai L (2000). "Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. PMC 86070. PMID 10913176. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86070. 
• Miller G, Panov KI, Friedrich JK et al (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=145519. 
• Kim NG, Rhee H, Li LS et al (2002). "Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability". Oncogene 21 (33): 5081–7. doi:10.1038/sj.onc.1205703. PMID 12140758. 
• Yuan X, Zhao J, Zentgraf H et al (2003). "Multiple interactions between RNA polymerase I, TIF-IA and TAFI subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC 1307603. PMID 12393749. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1307603. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Grandori C, Gomez-Roman N, Felton-Edkins ZA et al (2005). "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I". Nat. Cell Biol. 7 (3): 311–8. doi:10.1038/ncb1224. PMID 15723054. 
• Hillier LW, Graves TA, Fulton RS et al (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
• You KT, Li LS, Kim NG et al (2007). "Selective Translational Repression of Truncated Proteins from Frameshift Mutation-Derived mRNAs in Tumors". PLoS Biol. 5 (5): e109. doi:10.1371/journal.pbio.0050109. PMC 1854916. PMID 17456004. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1854916.