TAF1C

TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
Identifiers
Symbols	TAF1C; MGC:39976; SL1; TAFI110; TAFI95
External IDs	OMIM: 604905 MGI: 109576 HomoloGene: 21163 GeneCards: TAF1C Gene
Gene Ontology Molecular function • DNA binding Cellular component • nucleus • nucleoplasm • nucleoplasm Biological process • regulation of transcription, DNA-dependent • transcription from RNA polymerase I promoter • transcription initiation from RNA polymerase I promoter • transcription elongation from RNA polymerase I promoter • termination of RNA polymerase I transcription • transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9013	21341
Ensembl	ENSG00000103168	ENSMUSG00000031832
UniProt	Q15572	Q3U0N4
RefSeq (mRNA)	NM_005679.2	NM_021441.2
RefSeq (protein)	NP_005670.2	NP_067416.2
Location (UCSC)	Chr 16: 84.21 – 84.22 Mb	Chr 8: 122.12 – 122.13 Mb
PubMed search	[1]	[2]

TATA box-binding protein-associated factor RNA polymerase I subunit C is an enzyme that in humans is encoded by the TAF1C gene.

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.

Interactions

TAF1C has been shown to interact with UBTF.

Further reading

• Di Pietro C, Rapisarda A, Amico V, et al. (2000). "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1.". Cytogenet. Cell Genet. 89 (1-2): 133–6. doi:10.1159/000015592. PMID 10894955. 
• Zhai W, Comai L (2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53.". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. PMC 86070. PMID 10913176. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86070. 
• Miller G, Panov KI, Friedrich JK, et al. (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters.". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=145519. 
• Yuan X, Zhao J, Zentgraf H, et al. (2003). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC 1307603. PMID 12393749. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1307603. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Yamamoto K, Yamamoto M, Hanada K, et al. (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription.". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=434256. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Grandori C, Gomez-Roman N, Felton-Edkins ZA, et al. (2005). "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I.". Nat. Cell Biol. 7 (3): 311–8. doi:10.1038/ncb1224. PMID 15723054. 
• Friedrich JK, Panov KI, Cabart P, et al. (2005). "TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter.". J. Biol. Chem. 280 (33): 29551–8. doi:10.1074/jbc.M501595200. PMID 15970593. 
• Zhang C, Comai L, Johnson DL (2005). "PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex.". Mol. Cell. Biol. 25 (16): 6899–911. doi:10.1128/MCB.25.16.6899-6911.2005. PMC 1190253. PMID 16055704. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1190253. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.