Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2gene.
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators.
Parada CA, Yoon JB, Roeder RG (1995). "A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro.". J. Biol. Chem.270 (5): 2274–83. doi:10.1074/jbc.270.5.2274. PMID7836461.
Kashanchi F, Piras G, Radonovich MF, et al. (1994). "Direct interaction of human TFIID with the HIV-1 transactivator tat.". Nature367 (6460): 295–9. doi:10.1038/367295a0. PMID8121496.
Wang Z, Morris GF, Rice AP, et al. (1996). "Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro.". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol.12 (2): 128–38. doi:10.1097/00042560-199606010-00005. PMID8680883.
García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes.". J. Biol. Chem.272 (11): 6951–8. doi:10.1074/jbc.272.11.6951. PMID9054383.
Martinez E, Kundu TK, Fu J, Roeder RG (1998). "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID.". J. Biol. Chem.273 (37): 23781–5. doi:10.1074/jbc.273.37.23781. PMID9726987.
Brand M, Yamamoto K, Staub A, Tora L (1999). "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.". J. Biol. Chem.274 (26): 18285–9. doi:10.1074/jbc.274.26.18285. PMID10373431.