TAF4B

From Wikipedia, the free encyclopedia
Jump to: navigation, search
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
Identifiers
Symbols TAF4B ; SPGF13; TAF2C2; TAFII105
External IDs OMIM601689 MGI2152345 HomoloGene28266 GeneCards: TAF4B Gene
RNA expression pattern
PBB GE TAF4B gnf1h09648 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6875 72504
Ensembl ENSG00000141384 ENSMUSG00000054321
UniProt Q92750 G5E8Z2
RefSeq (mRNA) NM_001293725 NM_001100449
RefSeq (protein) NP_001280654 NP_001093919
Location (UCSC) Chr 18:
23.81 – 23.97 Mb
Chr 18:
14.78 – 14.9 Mb
PubMed search [1] [2]

Transcription initiation factor TFIID subunit 4B is a protein that in humans is encoded by the TAF4B gene.[1][2][3]

TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).[supplied by OMIM][3]

Interactions[edit]

TAF4B has been shown to interact with RELA.[4]

References[edit]

  1. ^ Dikstein R, Zhou S, Tjian R (Nov 1996). "Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130". Cell 87 (1): 137–46. doi:10.1016/S0092-8674(00)81330-6. PMID 8858156. 
  2. ^ Yamit-Hezi A, Nir S, Wolstein O, Dikstein R (Jul 2000). "Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes". J Biol Chem 275 (24): 18180–7. doi:10.1074/jbc.275.24.18180. PMID 10849440. 
  3. ^ a b "Entrez Gene: TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa". 
  4. ^ Yamit-Hezi, A; Dikstein R (Sep 1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. (ENGLAND) 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. ISSN 0261-4189. PMC 1170844. PMID 9724652. 

Further reading[edit]