TAF6

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
Identifiers
Symbols	TAF6; MGC:8964; TAF(II)70; TAF(II)80; TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85
External IDs	OMIM: 602955 MGI: 109129 HomoloGene: 7561 GeneCards: TAF6 Gene
Gene Ontology
Molecular function	• DNA binding; • sequence-specific DNA binding transcription factor activity; • sequence-specific DNA binding transcription factor activity; • protein binding;
Cellular component	• nucleus; • nucleoplasm; • transcription factor TFIID complex; • cytoplasm; • transcription factor TFTC complex; • MLL1 complex;
Biological process	• transcription initiation, DNA-dependent; • regulation of transcription, DNA-dependent; • transcription from RNA polymerase II promoter; • transcription from RNA polymerase II promoter; • transcription initiation from RNA polymerase II promoter; • transcription initiation from RNA polymerase II promoter; • transcription elongation from RNA polymerase II promoter; • negative regulation of cell proliferation; • gene expression; • viral reproduction; • negative regulation of cell cycle; • regulation of sequence-specific DNA binding transcription factor activity;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

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Transcription initiation factor TFIID subunit 6 is a protein that in humans is encoded by the TAF6 gene.^[1]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis.^[2]

[edit] Interactions

TAF6 has been shown to interact with TAF5^[3]^[4] and TATA binding protein.^[5]^[6]^[7]

[edit] References

^ Mathe G, Schwarzenberg L, Halle-Pannenko O, Simmler MC (January 1977). "Discussion paper: experimental and clinical immunopharmacology data applicable to cancer immunotherapy". Ann N Y Acad Sci 277 (00): 467–84. doi:10.1111/j.1749-6632.1976.tb41721.x. PMID 826207.
^ "Entrez Gene: TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6878.
^ Hsieh, Y J; Kundu T K, Wang Z, Kovelman R, Roeder R G (November 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7697–704. ISSN 0270-7306. PMC 84812. PMID 10523658. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84812.
^ Tao, Y; Guermah M, Martinez E, Oelgeschläger T, Hasegawa S, Takada R, Yamamoto T, Horikoshi M, Roeder R G (March 1997). "Specific interactions and potential functions of human TAFII100". J. Biol. Chem. (UNITED STATES) 272 (10): 6714–21. doi:10.1074/jbc.272.10.6714. ISSN 0021-9258. PMID 9045704.
^ Pointud, Jean-Christophe; Mengus Gabrielle, Brancorsini Stefano, Monaco Lucia, Parvinen Martti, Sassone-Corsi Paolo, Davidson Irwin (May 2003). "The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation". J. Cell. Sci. (England) 116 (Pt 9): 1847–58. doi:10.1242/jcs.00391. ISSN 0021-9533. PMID 12665565.
^ Bellorini, M; Lee D K, Dantonel J C, Zemzoumi K, Roeder R G, Tora L, Mantovani R (June 1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. (ENGLAND) 25 (11): 2174–81. doi:10.1093/nar/25.11.2174. ISSN 0305-1048. PMC 146709. PMID 9153318. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=146709.
^ Ruppert, S; Wang E H, Tjian R (March 1993). "Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation". Nature (ENGLAND) 362 (6416): 175–9. doi:10.1038/362175a0. ISSN 0028-0836. PMID 7680771.

[edit] Further reading

Klemm RD, Goodrich JA, Zhou S, Tjian R (1995). "Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation.". Proc. Natl. Acad. Sci. U.S.A. 92 (13): 5788–92. doi:10.1073/pnas.92.13.5788. PMC 41586. PMID 7597030. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=41586.
Chen HI, Sudol M (1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7819–23. doi:10.1073/pnas.92.17.7819. PMC 41237. PMID 7644498. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=41237.
Hisatake K, Ohta T, Takada R, et al. (1995). "Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 92 (18): 8195–9. doi:10.1073/pnas.92.18.8195. PMC 41123. PMID 7667268. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=41123.
Zhou Q, Sharp PA (1995). "Novel mechanism and factor for regulation by HIV-1 Tat.". EMBO J. 14 (2): 321–8. PMC 398086. PMID 7835343. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=398086.
Parada CA, Yoon JB, Roeder RG (1995). "A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro.". J. Biol. Chem. 270 (5): 2274–83. doi:10.1074/jbc.270.5.2274. PMID 7836461.
Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB (1994). "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function.". J. Virol. 68 (11): 7188–99. PMC 237158. PMID 7933101. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=237158.
Kashanchi F, Piras G, Radonovich MF, et al. (1994). "Direct interaction of human TFIID with the HIV-1 transactivator tat.". Nature 367 (6460): 295–9. doi:10.1038/367295a0. PMID 8121496.
Wang Z, Morris GF, Rice AP, et al. (1996). "Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro.". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (2): 128–38. doi:10.1097/00042560-199606010-00005. PMID 8680883.
Pendergrast PS, Morrison D, Tansey WP, Hernandez N (1996). "Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly.". J. Virol. 70 (8): 5025–34. PMC 190456. PMID 8764009. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=190456.
Kashanchi F, Khleif SN, Duvall JF, et al. (1996). "Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex.". J. Virol. 70 (8): 5503–10. PMC 190508. PMID 8764062. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=190508.
Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.". Science 274 (5287): 605–10. doi:10.1126/science.274.5287.605. PMID 8849451.
Tao Y, Guermah M, Martinez E, et al. (1997). "Specific interactions and potential functions of human TAFII100.". J. Biol. Chem. 272 (10): 6714–21. doi:10.1074/jbc.272.10.6714. PMID 9045704.
García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes.". J. Biol. Chem. 272 (11): 6951–8. doi:10.1074/jbc.272.11.6951. PMID 9054383.
Mahanta SK, Scholl T, Yang FC, Strominger JL (1997). "Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein.". Proc. Natl. Acad. Sci. U.S.A. 94 (12): 6324–9. doi:10.1073/pnas.94.12.6324. PMC 21048. PMID 9177216. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21048.
Guermah M, Malik S, Roeder RG (1998). "Involvement of TFIID and USA components in transcriptional activation of the human immunodeficiency virus promoter by NF-kappaB and Sp1.". Mol. Cell. Biol. 18 (6): 3234–44. PMC 108905. PMID 9584164. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=108905.
Brand M, Moggs JG, Oulad-Abdelghani M, et al. (2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation.". EMBO J. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203. PMID 11406595. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=150203.
Martinez E, Palhan VB, Tjernberg A, et al. (2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.". Mol. Cell. Biol. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99856.
Bell B, Scheer E, Tora L (2001). "Identification of hTAF(II)80 delta links apoptotic signaling pathways to transcription factor TFIID function.". Mol. Cell 8 (3): 591–600. doi:10.1016/S1097-2765(01)00325-2. PMID 11583621.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.

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[pmid826207-0] Mathe G, Schwarzenberg L, Halle-Pannenko O, Simmler MC (January 1977). "Discussion paper: experimental and clinical immunopharmacology data applicable to cancer immunotherapy". Ann N Y Acad Sci 277 (00): 467–84. doi:10.1111/j.1749-6632.1976.tb41721.x. PMID 826207.

[entrez-1] "Entrez Gene: TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6878.

[pmid10523658-2] Hsieh, Y J; Kundu T K, Wang Z, Kovelman R, Roeder R G (November 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7697–704. ISSN 0270-7306. PMC 84812. PMID 10523658. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84812.

[pmid9045704-3] Tao, Y; Guermah M, Martinez E, Oelgeschläger T, Hasegawa S, Takada R, Yamamoto T, Horikoshi M, Roeder R G (March 1997). "Specific interactions and potential functions of human TAFII100". J. Biol. Chem. (UNITED STATES) 272 (10): 6714–21. doi:10.1074/jbc.272.10.6714. ISSN 0021-9258. PMID 9045704.

[pmid12665565-4] Pointud, Jean-Christophe; Mengus Gabrielle, Brancorsini Stefano, Monaco Lucia, Parvinen Martti, Sassone-Corsi Paolo, Davidson Irwin (May 2003). "The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation". J. Cell. Sci. (England) 116 (Pt 9): 1847–58. doi:10.1242/jcs.00391. ISSN 0021-9533. PMID 12665565.

[pmid9153318-5] Bellorini, M; Lee D K, Dantonel J C, Zemzoumi K, Roeder R G, Tora L, Mantovani R (June 1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. (ENGLAND) 25 (11): 2174–81. doi:10.1093/nar/25.11.2174. ISSN 0305-1048. PMC 146709. PMID 9153318. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=146709.

[pmid7680771-6] Ruppert, S; Wang E H, Tjian R (March 1993). "Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation". Nature (ENGLAND) 362 (6416): 175–9. doi:10.1038/362175a0. ISSN 0028-0836. PMID 7680771.

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TAF6

[edit] Interactions

[edit] References

[edit] Further reading

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