TAF7

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TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
Identifiers
Symbols TAF7 ; TAF2F; TAFII55
External IDs OMIM600573 MGI1346348 HomoloGene133942 GeneCards: TAF7 Gene
RNA expression pattern
PBB GE TAF7 201023 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6879 24074
Ensembl ENSG00000178913 ENSMUSG00000051316
UniProt Q15545 Q9R1C0
RefSeq (mRNA) NM_005642 NM_175770
RefSeq (protein) NP_005633 NP_786964
Location (UCSC) Chr 5:
140.7 – 140.7 Mb
Chr 18:
37.64 – 37.64 Mb
PubMed search [1] [2]

Transcription initiation factor TFIID subunit 7 also known as TAFII55 is a protein that in humans is encoded by the TAF7 gene.[1]

The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II.[2]

TAFII55_N
Identifiers
Symbol TAFII55_N
Pfam PF04658
InterPro IPR006751

The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. TAFII55 binds to TAFII250 and inhibits its acetyltransferase activity. The exact role of TAFII55 is currently unknown but studies have shown that it interacts with the C-jun pathway.[3] The conserved region is situated towards the N-terminal of the protein.[4] This entry talks about the N-terminal domain.

Interactions[edit]

TAF7 has been shown to interact with TAF15,[5] TAF1[4] and TATA binding protein.[6][7]

References[edit]

  1. ^ Chiang CM, Roeder RG (February 1995). "Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators". Science 267 (5197): 531–6. doi:10.1126/science.7824954. PMID 7824954. 
  2. ^ "Entrez Gene: TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa". 
  3. ^ Munz C, Psichari E, Mandilis D, Lavigne AC, Spiliotaki M, Oehler T et al. (2003). "TAF7 (TAFII55) plays a role in the transcription activation by c-Jun.". J Biol Chem 278 (24): 21510–6. doi:10.1074/jbc.M212764200. PMID 12676957. 
  4. ^ a b Gegonne A, Weissman JD, Singer DS (October 2001). "TAFII55 binding to TAFII250 inhibits its acetyltransferase activity". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12432–7. doi:10.1073/pnas.211444798. PMC 60071. PMID 11592977. 
  5. ^ Bertolotti, A; Melot T; Acker J; Vigneron M; Delattre O; Tora L (March 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. (UNITED STATES) 18 (3): 1489–97. ISSN 0270-7306. PMC 108863. PMID 9488465. 
  6. ^ Pointud, Jean-Christophe; Mengus Gabrielle, Brancorsini Stefano, Monaco Lucia, Parvinen Martti, Sassone-Corsi Paolo, Davidson Irwin (May 2003). "The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation". J. Cell. Sci. (England) 116 (Pt 9): 1847–58. doi:10.1242/jcs.00391. ISSN 0021-9533. PMID 12665565. 
  7. ^ Bellorini, M; Lee D K; Dantonel J C; Zemzoumi K; Roeder R G; Tora L; Mantovani R (June 1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. (ENGLAND) 25 (11): 2174–81. doi:10.1093/nar/25.11.2174. ISSN 0305-1048. PMC 146709. PMID 9153318. 

Further reading[edit]

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