TAF8

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TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
Identifiers
Symbols TAF8 ; 43; II; TAF; TAFII-43; TAFII43; TBN
External IDs OMIM609514 MGI1926879 HomoloGene11094 GeneCards: TAF8 Gene
Orthologs
Species Human Mouse
Entrez 129685 63856
Ensembl ENSG00000137413 ENSMUSG00000023980
UniProt Q7Z7C8 Q9EQH4
RefSeq (mRNA) NM_138572 NM_022015
RefSeq (protein) NP_612639 NP_071298
Location (UCSC) Chr 6:
42.02 – 42.06 Mb
Chr 17:
47.49 – 47.5 Mb
PubMed search [1] [2]

Transcription initiation factor TFIID subunit 8 is a protein that in humans is encoded by the TAF8 gene.[1]

This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[1]

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