From Wikipedia, the free encyclopedia
Jump to: navigation, search
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
Symbols TAF9B ; DN-7; DN7; TAF9L; TAFII31L; TFIID-31
External IDs OMIM300754 MGI3039562 HomoloGene47969 GeneCards: TAF9B Gene
Species Human Mouse
Entrez 51616 407786
Ensembl ENSG00000187325 ENSMUSG00000047242
UniProt Q9HBM6 Q6NZA9
RefSeq (mRNA) NM_015975 NM_001001176
RefSeq (protein) NP_057059 NP_001001176
Location (UCSC) Chr HG1426_PATCH:
77.39 – 77.4 Mb
Chr X:
106.21 – 106.22 Mb
PubMed search [1] [2]

Transcription initiation factor TFIID subunit 9B is a protein that in humans is encoded by the TAF9B gene.[1][2]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process.[2]


Further reading[edit]