TAL1

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T-cell acute lymphocytic leukemia 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TAL1 ; SCL; TCL5; bHLHa17; tal-1
External IDs OMIM187040 MGI98480 HomoloGene2400 GeneCards: TAL1 Gene
RNA expression pattern
PBB GE TAL1 206283 s at tn.png
PBB GE TAL1 216925 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6886 21349
Ensembl ENSG00000162367 ENSMUSG00000028717
UniProt P17542 P22091
RefSeq (mRNA) NM_001287347 NM_001287388
RefSeq (protein) NP_001274276 NP_001274317
Location (UCSC) Chr 1:
47.68 – 47.7 Mb
Chr 4:
115.06 – 115.07 Mb
PubMed search [1] [2]

T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene.[1][2]

The protein encoded by TAL1 is a basic helix-loop-helix transcription factor.

Interactions[edit]

TAL1 has been shown to interact with:

References[edit]

  1. ^ Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC et al. (August 1989). "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma". Proc Natl Acad Sci U S A 86 (13): 5039–43. doi:10.1073/pnas.86.13.5039. PMC 297552. PMID 2740341. 
  2. ^ "Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1". 
  3. ^ a b c d e Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P et al. (January 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. PMC 1383517. PMID 16407974. 
  4. ^ Huang S, Qiu Y, Stein RW, Brandt SJ (September 1999). "p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein". Oncogene 18 (35): 4958–67. doi:10.1038/sj.onc.1202889. PMID 10490830. 
  5. ^ a b Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (October 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177. 
  6. ^ a b Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R et al. (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932. 
  7. ^ a b Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH et al. (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. PMC 395422. PMID 7957052. 
  8. ^ Huang S, Brandt SJ (March 2000). "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor". Mol. Cell. Biol. 20 (6): 2248–59. doi:10.1128/mcb.20.6.2248-2259.2000. PMC 110841. PMID 10688671. 
  9. ^ Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C et al. (October 2002). "The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1". Blood 100 (7): 2430–40. doi:10.1182/blood-2002-02-0568. PMID 12239153. 
  10. ^ Hsu HL, Wadman I, Baer R (April 1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. doi:10.1073/pnas.91.8.3181. PMC 43539. PMID 8159721. 

Further reading[edit]

External links[edit]