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T-cell acute lymphocytic leukemia 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TAL1 ; SCL; TCL5; bHLHa17; tal-1
External IDs OMIM187040 MGI98480 HomoloGene2400 GeneCards: TAL1 Gene
RNA expression pattern
PBB GE TAL1 206283 s at tn.png
PBB GE TAL1 216925 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6886 21349
Ensembl ENSG00000162367 ENSMUSG00000028717
UniProt P17542 P22091
RefSeq (mRNA) NM_001287347 NM_001287388
RefSeq (protein) NP_001274276 NP_001274317
Location (UCSC) Chr 1:
47.68 – 47.7 Mb
Chr 4:
115.06 – 115.07 Mb
PubMed search [1] [2]

T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene.[1][2]

The protein encoded by TAL1 is a basic helix-loop-helix transcription factor.


TAL1 has been shown to interact with LMO1,[3][4] LDB1,[5] SIN3A,[6] LMO2,[3][4][5][7] Sp1 transcription factor,[8] TCF3,[5][9] CBFA2T3,[5] EP300[10] and GATA1.[5][7]


  1. ^ Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (August 1989). "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma". Proc Natl Acad Sci U S A 86 (13): 5039–43. doi:10.1073/pnas.86.13.5039. PMC 297552. PMID 2740341. 
  2. ^ "Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1". 
  3. ^ a b Valge-Archer, V E; Osada H; Warren A J; Forster A; Li J; Baer R; Rabbitts T H (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (18): 8617–21. doi:10.1073/pnas.91.18.8617. ISSN 0027-8424. PMC 44657. PMID 8078932. 
  4. ^ a b Wadman, I; Li J; Bash R O; Forster A; Osada H; Rabbitts T H; Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. (ENGLAND) 13 (20): 4831–9. ISSN 0261-4189. PMC 395422. PMID 7957052. 
  5. ^ a b c d e Goardon, Nicolas; Lambert Julie A; Rodriguez Patrick; Nissaire Philippe; Herblot Sabine; Thibault Pierre; Dumenil Dominique; Strouboulis John; Romeo Paul-Henri; Hoang Trang (January 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. (England) 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. ISSN 0261-4189. PMC 1383517. PMID 16407974. 
  6. ^ Huang, S; Brandt S J (March 2000). "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor". Mol. Cell. Biol. (UNITED STATES) 20 (6): 2248–59. doi:10.1128/MCB.20.6.2248-2259.2000. ISSN 0270-7306. PMC 110841. PMID 10688671. 
  7. ^ a b Osada, H; Grutz G; Axelson H; Forster A; Rabbitts T H (October 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. ISSN 0027-8424. PMC 40846. PMID 7568177. 
  8. ^ Lécuyer, Eric; Herblot Sabine, Saint-Denis Marianne, Martin Richard, Begley C Glenn, Porcher Catherine, Orkin Stuart H, Hoang Trang (October 2002). "The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1". Blood (United States) 100 (7): 2430–40. doi:10.1182/blood-2002-02-0568. ISSN 0006-4971. PMID 12239153. 
  9. ^ Hsu, H L; Wadman I; Baer R (April 1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (8): 3181–5. doi:10.1073/pnas.91.8.3181. ISSN 0027-8424. PMC 43539. PMID 8159721. 
  10. ^ Huang, S; Qiu Y; Stein R W; Brandt S J (September 1999). "p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein". Oncogene (ENGLAND) 18 (35): 4958–67. doi:10.1038/sj.onc.1202889. ISSN 0950-9232. PMID 10490830. 

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