TAL2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
T-cell acute lymphocytic leukemia 2
Identifiers
Symbol TAL2
External IDs OMIM186855 MGI99540 HomoloGene3954 GeneCards: TAL2 Gene
Orthologs
Species Human Mouse
Entrez 6887 21350
Ensembl ENSG00000186051 ENSMUSG00000028417
UniProt Q16559 Q62282
RefSeq (mRNA) NM_005421 NM_009317
RefSeq (protein) NP_005412 NP_033343
Location (UCSC) Chr 9:
108.42 – 108.43 Mb
Chr 4:
53.78 – 53.79 Mb
PubMed search [1] [2]

T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene.[1][2]

Function[edit]

TAL2 is a member of the basic helix-loop-helix family of transcription factors.[3]

Clinical significance[edit]

Tumor-specific alterations of the TAL2 gene occurs in some patients with T-cell acute lymphoblastic leukemia (T-ALL).[2][4]

References[edit]

  1. ^ "Entrez Gene: TAL2 T-cell acute lymphocytic leukemia 2". 
  2. ^ a b Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ (December 1991). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. doi:10.1073/pnas.88.24.11416. PMC 53146. PMID 1763056. 
  3. ^ Baer R (December 1993). "TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia". Semin. Cancer Biol. 4 (6): 341–7. PMID 8142619. 
  4. ^ Marculescu R, Vanura K, Le T, Simon P, Jäger U, Nadel B (March 2003). "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL". Nat. Genet. 33 (3): 342–4. doi:10.1038/ng1092. PMID 12567187. 

Further reading[edit]