TANK (gene)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
TRAF family member-associated NFKB activator
PDB 1kzz EBI.jpg
Rendering of TANK from PDB 1KZZ
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM603893 MGI107676 HomoloGene3081 GeneCards: TANK Gene
RNA expression pattern
PBB GE TANK 209451 at tn.png
PBB GE TANK 207616 s at tn.png
PBB GE TANK 210458 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10010 21353
Ensembl ENSG00000136560 ENSMUSG00000064289
UniProt Q92844 P70347
RefSeq (mRNA) NM_001199135 NM_001164071
RefSeq (protein) NP_001186064 NP_001157543
Location (UCSC) Chr 2:
161.99 – 162.09 Mb
Chr 2:
61.58 – 61.65 Mb
PubMed search [1] [2]

TRAF family member-associated NF-kappa-B activator is a protein that in humans is encoded by the TANK gene.[1][2][3]

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.[3]


TANK (gene) has been shown to interact with TANK-binding kinase 1,[4][5] IKBKE,[6] TRAF2,[1][4][5][6] IKBKG[7] and TRAF3.[1][4]


  1. ^ a b c Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV (September 1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction". Proc Natl Acad Sci U S A 93 (16): 8241–6. doi:10.1073/pnas.93.16.8241. PMC 38654. PMID 8710854. 
  2. ^ Kaye KM, Devergne O, Harada JN, Izumi KM, Yalamanchili R, Kieff E, Mosialos G (November 1996). "Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein". Proc Natl Acad Sci U S A 93 (20): 11085–90. doi:10.1073/pnas.93.20.11085. PMC 38288. PMID 8855313. 
  3. ^ a b "Entrez Gene: TANK TRAF family member-associated NFKB activator". 
  4. ^ a b c Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216. 
  5. ^ a b Pomerantz, J L; Baltimore D (December 1999). "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase". EMBO J. (ENGLAND) 18 (23): 6694–704. doi:10.1093/emboj/18.23.6694. ISSN 0261-4189. PMC 1171732. PMID 10581243. 
  6. ^ a b Nomura, F; Kawai T; Nakanishi K; Akira S (March 2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation". Genes Cells (ENGLAND) 5 (3): 191–202. doi:10.1046/j.1365-2443.2000.00315.x. ISSN 1356-9597. PMID 10759890. 
  7. ^ Chariot, Alain; Leonardi Antonio; Muller Jurgen; Bonif Marianne; Brown Keith; Siebenlist Ulrich (October 2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases". J. Biol. Chem. (United States) 277 (40): 37029–36. doi:10.1074/jbc.M205069200. ISSN 0021-9258. PMID 12133833. 

Further reading[edit]

External links[edit]