TAP1

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Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Protein TAP1 PDB 1jj7.png
PDB rendering based on 1jj7.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TAP1 ; ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1; RING4; TAP1*0102N; TAP1N
External IDs OMIM170260 MGI98483 HomoloGene495 GeneCards: TAP1 Gene
RNA expression pattern
PBB GE TAP1 202307 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6890 21354
Ensembl ENSG00000168394 ENSMUSG00000037321
UniProt Q03518 P21958
RefSeq (mRNA) NM_000593 NM_001161730
RefSeq (protein) NP_000584 NP_001155202
Location (UCSC) Chr 6:
32.81 – 32.82 Mb
Chr 17:
34.19 – 34.2 Mb
PubMed search [1] [2]

Transporter associated with Antigen Processing 1 is a protein that in humans is encoded by the TAP1 gene.[1][2]

Function[edit]

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.[3]

See also[edit]

Interactions[edit]

TAP1 has been shown to interact with:

References[edit]

  1. ^ Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA et al. (Oct 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens 39 (4): 161–73. doi:10.1111/j.1399-0039.1992.tb01932.x. PMID 1529427. 
  2. ^ Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T (Dec 1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc Natl Acad Sci U S A 88 (22): 10094–8. doi:10.1073/pnas.88.22.10094. PMC 52874. PMID 1946428. 
  3. ^ "Entrez Gene: TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)". 
  4. ^ a b Paulsson KM, Kleijmeer MJ, Griffith J, Jevon M, Chen S, Anderson PO et al. (May 2002). "Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum". J. Biol. Chem. 277 (21): 18266–71. doi:10.1074/jbc.M201388200. PMID 11884415. 
  5. ^ Raghuraman G, Lapinski PE, Raghavan M (Nov 2002). "Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes". J. Biol. Chem. 277 (44): 41786–94. doi:10.1074/jbc.M207128200. PMID 12213826. 


Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.