TAP1

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Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Protein TAP1 PDB 1jj7.png
PDB rendering based on 1jj7.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TAP1 ; ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1; RING4; TAP1*0102N; TAP1N
External IDs OMIM170260 MGI98483 HomoloGene495 GeneCards: TAP1 Gene
RNA expression pattern
PBB GE TAP1 202307 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6890 21354
Ensembl ENSG00000168394 ENSMUSG00000037321
UniProt Q03518 P21958
RefSeq (mRNA) NM_000593 NM_001161730
RefSeq (protein) NP_000584 NP_001155202
Location (UCSC) Chr 6:
32.81 – 32.82 Mb
Chr 17:
34.19 – 34.2 Mb
PubMed search [1] [2]

Transporter associated with Antigen Processing 1 is a protein that in humans is encoded by the TAP1 gene.[1][2]

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.[3]

See also[edit]

Interactions[edit]

TAP1 has been shown to interact with Tapasin[4][5] and HLA-A.[5]

References[edit]

  1. ^ Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P (Oct 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens 39 (4): 161–73. doi:10.1111/j.1399-0039.1992.tb01932.x. PMID 1529427. 
  2. ^ Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T (Dec 1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc Natl Acad Sci U S A 88 (22): 10094–8. doi:10.1073/pnas.88.22.10094. PMC 52874. PMID 1946428. 
  3. ^ "Entrez Gene: TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)". 
  4. ^ Raghuraman, Gayatri; Lapinski Philip Edward; Raghavan Malini (Nov 2002). "Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes". J. Biol. Chem. (United States) 277 (44): 41786–94. doi:10.1074/jbc.M207128200. ISSN 0021-9258. PMID 12213826. 
  5. ^ a b Paulsson, Kajsa M; Kleijmeer Monique J; Griffith Janice; Jevon Marc; Chen Shangwu; Anderson Per O; Sjogren Hans-Olov; Li Suling; Wang Ping (May 2002). "Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum". J. Biol. Chem. (United States) 277 (21): 18266–71. doi:10.1074/jbc.M201388200. ISSN 0021-9258. PMID 11884415. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.