TAS2R16

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Taste receptor, type 2, member 16
Identifiers
Symbols TAS2R16 ; T2R16
External IDs OMIM604867 MGI2681247 HomoloGene9660 IUPHAR: TAS2R16 GeneCards: TAS2R16 Gene
RNA expression pattern
PBB GE TAS2R16 221444 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 50833 387347
Ensembl ENSG00000128519 ENSMUSG00000043865
UniProt Q9NYV7 P59529
RefSeq (mRNA) NM_016945 NM_207022
RefSeq (protein) NP_058641 NP_996905
Location (UCSC) Chr 7:
122.63 – 122.64 Mb
Chr 6:
23.97 – 23.97 Mb
PubMed search [1] [2]

TAS2R16 (taste receptor, type 2, member 16) is a human gene that encodes for a receptor that may play a role in the perception of bitterness. [1][2]

The TAS2R16 gene is located on the long (q) arm of chromosome 7 at position 31.1 - 31.3, from base pair 122,228,764 to base pair 122,229,639.

Clinical significance[edit]

Variants of this gene have been linked to an increased risk for alcohol dependence.[3]

There is an East African origin for high salicin sensitivity, and thus sensitivity to bitterness in people from this region, with this phenotype matched to TAS2R16 variants.[4]

See also[edit]

References[edit]

  1. ^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855. 
  2. ^ Drewnowski A (2001). "The science and complexity of bitter taste". Nutr Rev 59 (6): 163–9. doi:10.1111/j.1753-4887.2001.tb07007.x. PMID 11444592. 
  3. ^ Hinrichs AL, Wang JC, Bufe B, Kwon JM, Budde J, Allen R, Bertelsen S, Evans W, Dick D, Rice J, Foroud T, Nurnberger J, Tischfield JA, Kuperman S, Crowe R, Hesselbrock V, Schuckit M, Almasy L, Porjesz B, Edenberg HJ, Begleiter H, Meyerhof W, Bierut LJ, Goate AM (2006). "Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence". Am. J. Hum. Genet. 78 (1): 103–11. doi:10.1086/499253. PMC 1380207. PMID 16385453. 
  4. ^ Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Rucker JB, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA (2014). "Origin and Differential Selection of Allelic Variation at TAS2R16 Associated with Salicin Bitter Taste Sensitivity in Africa". Mol Biol Evol 31 (2): 288–302. doi:10.1093/molbev/mst211. PMID 24177185. 

Further reading[edit]

External links[edit]