From Wikipedia, the free encyclopedia
Jump to: navigation, search
Taste receptor, type 2, member 4
Symbols TAS2R4 ; T2R4
External IDs OMIM604869 MGI2681210 HomoloGene49480 IUPHAR: 661 GeneCards: TAS2R4 Gene
RNA expression pattern
PBB GE TAS2R4 221392 at tn.png
More reference expression data
Species Human Mouse
Entrez 50832 57253
Ensembl ENSG00000127364 ENSMUSG00000037140
UniProt Q9NYW5 Q9JKT3
RefSeq (mRNA) NM_016944 NM_020502
RefSeq (protein) NP_058640 NP_065248
Location (UCSC) Chr 7:
141.48 – 141.48 Mb
Chr 6:
40.49 – 40.49 Mb
PubMed search [1] [2]

Taste receptor type 2 member 4 is a protein that in humans is encoded by the TAS2R4 gene.[1][2][3]


This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.[3]

See also[edit]


  1. ^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934. 
  2. ^ Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (Apr 2000). "T2Rs function as bitter taste receptors". Cell 100 (6): 703–11. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935. 
  3. ^ a b "Entrez Gene: TAS2R4 taste receptor, type 2, member 4". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.