From Wikipedia, the free encyclopedia
Jump to: navigation, search
Tax1 (human T-cell leukemia virus type I) binding protein 3
Protein TAX1BP3 PDB 2KG2.png
Rendering based on PDB 2KG2.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TAX1BP3 ; TIP-1
External IDs MGI1923531 HomoloGene8749 GeneCards: TAX1BP3 Gene
Species Human Mouse
Entrez 30851 76281
Ensembl ENSG00000213977 ENSMUSG00000040158
UniProt O14907 Q9DBG9
RefSeq (mRNA) NM_001204698 NM_029564
RefSeq (protein) NP_001191627 NP_083840
Location (UCSC) Chr 17:
3.57 – 3.57 Mb
Chr 11:
73.18 – 73.18 Mb
PubMed search [1] [2]

Tax1-binding protein 3 is a protein that in humans is encoded by the TAX1BP3 gene.[1][2][3] This name is in reference to the Tax1 protein of the Human T-cell Lymphotropic Virus (HTLV)which was used to discover Tax1BP3 in a yeast 2-hybrid screen and subsequently verified by co-IP. TIP1, as it is also known, is a PDZ domain containing protein. However, unlike most PDZ domain proteins which act as scaffolds and often contain multiple PDZ domains as well as other protein domains, TIP1 is essentially just the PDZ domain. This has led to the speculation that TIP1 acts as an inhibitor, either acting to separate PDZ binding motifs from their normal targets or simply preventing the protein to migrate away from the cytosol.


  1. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  2. ^ Touchman JW, Anikster Y, Dietrich NL, Maduro VV, McDowell G, Shotelersuk V, Bouffard GG, Beckstrom-Sternberg SM, Gahl WA, Green ED (Mar 2000). "The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion". Genome Res 10 (2): 165–73. doi:10.1101/gr.10.2.165. PMC 310836. PMID 10673275. 
  3. ^ "Entrez Gene: TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3". 

Further reading[edit]