Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that serves the same function as TBP and substitutes for TBP at some promoters that are not recognized by TFIID. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes.
^Ohbayashi T, Kishimoto T, Makino Y, Shimada M, Nakadai T, Aoki T, Kawata T, Niwa S, Tamura T (Dec 1999). "Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein". Biochem Biophys Res Commun255 (1): 137–42. doi:10.1006/bbrc.1999.0159. PMID10082669.
Martianov I, Brancorsini S, Gansmuller A et al. (2002). "Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids.". Development129 (4): 945–55. PMID11861477.CS1 maint: Explicit use of et al. (link)
Mungall AJ, Palmer SA, Sims SK et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature425 (6960): 805–11. doi:10.1038/nature02055. PMID14574404.CS1 maint: Explicit use of et al. (link)
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.CS1 maint: Explicit use of et al. (link)