TBX2

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T-box 2
Protein TBX2 PDB 1h6f.png
PDB rendering based on 1h6f.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TBX2 ; FLJ10169
External IDs OMIM600747 MGI98494 HomoloGene38123 GeneCards: TBX2 Gene
RNA expression pattern
PBB GE TBX2 40560 at tn.png
PBB GE TBX2 205993 s at tn.png
PBB GE TBX2 213417 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6909 21385
Ensembl ENSG00000121068 ENSMUSG00000000093
UniProt Q13207 Q60707
RefSeq (mRNA) NM_005994 NM_009324
RefSeq (protein) NP_005985 NP_033350
Location (UCSC) Chr 17:
59.48 – 59.49 Mb
Chr 11:
85.83 – 85.84 Mb
PubMed search [1] [2]

T-box transcription factor TBX2 is a protein that in humans is encoded by the TBX2 gene.[1][2]

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.[2]

In melanocytic cell types, expression of the T-box 2 gene is regulated by the Microphthalmia-associated transcription factor.[3][4]

References[edit]

  1. ^ Campbell C, Goodrich K, Casey G, Beatty B (Feb 1996). "Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene". Genomics 28 (2): 255–60. doi:10.1006/geno.1995.1139. PMID 8530034. 
  2. ^ a b "Entrez Gene: TBX2 T-box 2". 
  3. ^ Carreira S, Liu B, Goding CR (2000). "The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes". J. Biol. Chem. 275 (29): 21920–7. doi:10.1074/jbc.M000035200. PMID 10770922. 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

Further reading[edit]

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