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Protein TCAP PDB 1ya5.png
PDB rendering based on 1ya5.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TCAP ; CMD1N; LGMD2G; T-cap; TELE; telethonin
External IDs OMIM604488 MGI1330233 HomoloGene2724 GeneCards: TCAP Gene
RNA expression pattern
PBB GE TCAP 205766 at tn.png
More reference expression data
Species Human Mouse
Entrez 8557 21393
Ensembl ENSG00000173991 ENSMUSG00000007877
UniProt O15273 O70548
RefSeq (mRNA) NM_003673 NM_011540
RefSeq (protein) NP_003664 NP_035670
Location (UCSC) Chr 17:
37.82 – 37.82 Mb
Chr 11:
98.38 – 98.38 Mb
PubMed search [1] [2]

Telethonin is a protein that in humans is encoded by the TCAP gene.[1][2][3]

Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G.[3]


Telethonin has been shown to interact with Titin,[2][4][5][6] MYOZ1[7][8] and ANKRD2.[9]


  1. ^ Valle G, Faulkner G, De Antoni A, Pacchioni B, Pallavicini A, Pandolfo D, Tiso N, Toppo S, Trevisan S, Lanfranchi G (November 1997). "Telethonin, a novel sarcomeric protein of heart and skeletal muscle". FEBS Lett 415 (2): 163–8. doi:10.1016/S0014-5793(97)01108-3. PMID 9350988. 
  2. ^ a b Gregorio CC, Trombitas K, Centner T, Kolmerer B, Stier G, Kunke K, Suzuki K, Obermayr F, Herrmann B, Granzier H, Sorimachi H, Labeit S (December 1998). "The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity". J Cell Biol 143 (4): 1013–27. doi:10.1083/jcb.143.4.1013. PMC 2132961. PMID 9817758. 
  3. ^ a b "Entrez Gene: TCAP titin-cap (telethonin)". 
  4. ^ Mayans, O; van der Ven P F, Wilm M, Mues A, Young P, Fürst D O, Wilmanns M, Gautel M (October 1998). "Structural basis for activation of the titin kinase domain during myofibrillogenesis". Nature (ENGLAND) 395 (6705): 863–9. doi:10.1038/27603. ISSN 0028-0836. PMID 9804419. 
  5. ^ Zou, Peijian; Gautel Mathias; Geerlof Arie; Wilmanns Matthias; Koch Michel H J; Svergun Dmitri I (January 2003). "Solution scattering suggests cross-linking function of telethonin in the complex with titin". J. Biol. Chem. (United States) 278 (4): 2636–44. doi:10.1074/jbc.M210217200. ISSN 0021-9258. PMID 12446666. 
  6. ^ Mues, A; van der Ven P F, Young P, Fürst D O, Gautel M (May 1998). "Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin". FEBS Lett. (NETHERLANDS) 428 (1-2): 111–4. doi:10.1016/S0014-5793(98)00501-8. ISSN 0014-5793. PMID 9645487. 
  7. ^ Frey, Norbert; Olson Eric N (April 2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins". J. Biol. Chem. (United States) 277 (16): 13998–4004. doi:10.1074/jbc.M200712200. ISSN 0021-9258. PMID 11842093. 
  8. ^ Faulkner, G; Pallavicini A, Comelli A, Salamon M, Bortoletto G, Ievolella C, Trevisan S, Kojic' S, Dalla Vecchia F, Laveder P, Valle G, Lanfranchi G (December 2000). "FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle". J. Biol. Chem. (UNITED STATES) 275 (52): 41234–42. doi:10.1074/jbc.M007493200. ISSN 0021-9258. PMID 10984498. 
  9. ^ Kojic, Snezana; Medeot Elisa; Guccione Ernesto; Krmac Helena; Zara Ivano; Martinelli Valentina; Valle Giorgio; Faulkner Georgine (May 2004). "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle". J. Mol. Biol. (England) 339 (2): 313–25. doi:10.1016/j.jmb.2004.03.071. ISSN 0022-2836. PMID 15136035. 

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