TCEB2

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Transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
Protein TCEB2 PDB 1lm8.png
PDB rendering based on 1lm8.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TCEB2 ; ELOB; SIII
External IDs OMIM600787 MGI1914923 HomoloGene134544 GeneCards: TCEB2 Gene
Orthologs
Species Human Mouse
Entrez 6923 67673
Ensembl ENSG00000103363 ENSMUSG00000055839
UniProt Q15370 P62869
RefSeq (mRNA) NM_007108 NM_026305
RefSeq (protein) NP_009039 NP_080581
Location (UCSC) Chr 16:
2.77 – 2.78 Mb
Chr 17:
23.82 – 23.83 Mb
PubMed search [1] [2]

Transcription elongation factor B polypeptide 2 is a protein that in humans is encoded by the TCEB2 gene.[1]

Function[edit]

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[2]

Interactions[edit]

TCEB2 has been shown to interact with:

References[edit]

  1. ^ Garrett KP, Aso T, Bradsher JN, Foundling SI, Lane WS, Conaway RC et al. (September 1995). "Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog". Proc Natl Acad Sci U S A 92 (16): 7172–6. doi:10.1073/pnas.92.16.7172. PMC 41301. PMID 7638163. 
  2. ^ "Entrez Gene: TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)". 
  3. ^ a b Menon S, Tsuge T, Dohmae N, Takio K, Wei N. "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome". BMC Biochem. 9: 1. doi:10.1186/1471-2091-9-1. PMC 2265268. PMID 18173839. 
  4. ^ Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E et al. (August 2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase". J. Biol. Chem. 276 (32): 29748–53. doi:10.1074/jbc.M103093200. PMID 11384984. 
  5. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  6. ^ a b Ohh M, Takagi Y, Aso T, Stebbins CE, Pavletich NP, Zbar B et al. (Dec 1999). "Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein". J. Clin. Invest. 104 (11): 1583–91. doi:10.1172/JCI8161. PMC 481054. PMID 10587522. 
  7. ^ Krumm A, Groudine M (September 1995). "Tumor suppression and transcription elongation: the dire consequences of changing partners". Science 269 (5229): 1400–1. doi:10.1126/science.7660121. PMID 7660121. 
  8. ^ Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (February 2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7): 4656–62. doi:10.1074/jbc.M108269200. PMID 11739384. 
  9. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  10. ^ Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP (June 2002). "Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling". Science 296 (5574): 1886–9. doi:10.1126/science.1073440. PMID 12004076. 
  11. ^ Hacker KE, Lee CM, Rathmell WK. Zhang B, ed. "VHL type 2B mutations retain VBC complex form and function". PLoS ONE 3 (11): e3801. doi:10.1371/journal.pone.0003801. PMC 2583047. PMID 19030229. 

Further reading[edit]