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Transcription factor 12
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TCF12 ; CRS3; HEB; HTF4; HsT17266; bHLHb20
External IDs OMIM600480 MGI101877 HomoloGene40774 GeneCards: TCF12 Gene
RNA expression pattern
PBB GE TCF12 208986 at tn.png
More reference expression data
Species Human Mouse
Entrez 6938 21406
Ensembl ENSG00000140262 ENSMUSG00000032228
UniProt Q99081 Q61286
RefSeq (mRNA) NM_003205 NM_001253862
RefSeq (protein) NP_003196 NP_001240791
Location (UCSC) Chr 15:
57.21 – 57.59 Mb
Chr 9:
71.84 – 72.11 Mb
PubMed search [1] [2]

Transcription factor 12 is a protein that in humans is encoded by the TCF12 gene.[1][2]

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[2]

Mutations in this gene have been associated to cases of coronal craniosynostosis (doi: 10.1038/ng.2531)


  1. ^ Zhang Y, Babin J, Feldhaus AL, Singh H, Sharp PA, Bina M (Oct 1991). "HTF4: a new human helix-loop-helix protein". Nucleic Acids Res 19 (16): 4555. doi:10.1093/nar/19.16.4555. PMC 328652. PMID 1886779. 
  2. ^ a b "Entrez Gene: TCF12 transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)". 

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