TCF21 is a tumor suppressor gene which regulates mesenchymal cell transition into epithelial cells. It is frequently lost in human malignancies and is expressed in normal lung airway epithelial cells. It is silenced in the majority of head and neck squamous cell carcinomas and non-small-cell lung cancer tumor cells through a chemical change known as DNA methylation, a process that is potentially reversible.
The gene is located on chromosome 6, in region 6q23-q24.
- Smith LT, Lin M, Brena RM, Lang JC, Schuller DE, Otterson GA, Morrison CD, Smiraglia DJ, Plass C (2006). "Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer". Proc Natl Acad Sci USA 103 (4): 982–7. doi:10.1073/pnas.0510171102. PMC 1348006. PMID 16415157.
- Ohio State University press release
- Science Daily article
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