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T-cell leukemia/lymphoma 1A
Protein TCL1A PDB 1jsg.png
PDB rendering based on 1jsg.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TCL1A ; TCL1
External IDs OMIM186960 MGI1097166 HomoloGene7565 GeneCards: TCL1A Gene
RNA expression pattern
PBB GE TCL1A 39318 at tn.png
PBB GE TCL1A 209995 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8115 21432
Ensembl ENSG00000100721 ENSMUSG00000041359
UniProt P56279 P56280
RefSeq (mRNA) NM_001098725 NM_001289468
RefSeq (protein) NP_001092195 NP_001276397
Location (UCSC) Chr 14:
96.18 – 96.18 Mb
Chr 12:
105.22 – 105.22 Mb
PubMed search [1] [2]

T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene.[1][2][3]


TCL1A has been shown to interact with AKT1[4][5][6] and AKT2.[4][5]


  1. ^ Russo G, Isobe M, Gatti R, Finan J, Batuman O, Huebner K, Nowell PC, Croce CM (February 1989). "Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient". Proc Natl Acad Sci U S A 86 (2): 602–6. doi:10.1073/pnas.86.2.602. PMC 286520. PMID 2783489. 
  2. ^ Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G (February 1995). "Identification of the TCL1 gene involved in T-cell malignancies". Proc Natl Acad Sci U S A 91 (26): 12530–4. doi:10.1073/pnas.91.26.12530. PMC 45472. PMID 7809072. 
  3. ^ "Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A". 
  4. ^ a b Laine, Jarmo; Künstle Gerald; Obata Toshiyuki; Noguchi Masayuki (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. (United States) 277 (5): 3743–51. doi:10.1074/jbc.M107069200. ISSN 0021-9258. PMID 11707444. 
  5. ^ a b Laine, J; Künstle G; Obata T; Sha M; Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell (UNITED STATES) 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. ISSN 1097-2765. PMID 10983986. 
  6. ^ French, Samuel W; Shen Rhine R; Koh Patricia J; Malone Cindy S; Mallick Parag; Teitell Michael A (May 2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry (United States) 41 (20): 6376–82. doi:10.1021/bi016068o. ISSN 0006-2960. PMID 12009899. 

Further reading[edit]