TCL1A
From Wikipedia, the free encyclopedia
| T-cell leukemia/lymphoma 1A | |||||||||||||
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 PDB rendering based on 1jsg. |
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| Identifiers | |||||||||||||
| Symbols | TCL1A; TCL1 | ||||||||||||
| External IDs | OMIM: 186960 MGI: 1097166 HomoloGene: 7565 GeneCards: TCL1A Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8115 | 21432 | |||||||||||
| Ensembl | ENSG00000100721 | ENSMUSG00000041359 | |||||||||||
| UniProt | P56279 | P56280 | |||||||||||
| RefSeq (mRNA) | NM_001098725.1 | NM_009337.3 | |||||||||||
| RefSeq (protein) | NP_001092195.1 | NP_033363.1 | |||||||||||
| Location (UCSC) | Chr 14: 96.18 – 96.18 Mb |
Chr 12: 106.45 – 106.46 Mb |
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| PubMed search | [1] | [2] | |||||||||||
T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene.[1][2][3]
[edit] Interactions
TCL1A has been shown to interact with AKT1[4][5][6] and AKT2.[4][5]
[edit] References
- ^ Russo G, Isobe M, Gatti R, Finan J, Batuman O, Huebner K, Nowell PC, Croce CM (Feb 1989). "Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient". Proc Natl Acad Sci U S A 86 (2): 602–6. doi:10.1073/pnas.86.2.602. PMC 286520. PMID 2783489. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=286520.
- ^ Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G (Feb 1995). "Identification of the TCL1 gene involved in T-cell malignancies". Proc Natl Acad Sci U S A 91 (26): 12530–4. doi:10.1073/pnas.91.26.12530. PMC 45472. PMID 7809072. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=45472.
- ^ "Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8115.
- ^ a b Laine, Jarmo; Künstle Gerald, Obata Toshiyuki, Noguchi Masayuki (Feb. 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. (United States) 277 (5): 3743–51. doi:10.1074/jbc.M107069200. ISSN 0021-9258. PMID 11707444.
- ^ a b Laine, J; Künstle G, Obata T, Sha M, Noguchi M (Aug. 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell (UNITED STATES) 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. ISSN 1097-2765. PMID 10983986.
- ^ French, Samuel W; Shen Rhine R, Koh Patricia J, Malone Cindy S, Mallick Parag, Teitell Michael A (May. 2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry (United States) 41 (20): 6376–82. doi:10.1021/bi016068o. ISSN 0006-2960. PMID 12009899.
[edit] Further reading
- Pekarsky Y, Hallas C, Croce CM (2001). "The role of TCL1 in human T-cell leukemia". Oncogene 20 (40): 5638–43. doi:10.1038/sj.onc.1204596. PMID 11607815.
- Pekarsky Y, Zanesi N, Aqeilan R, Croce CM (2004). "Tcl1 as a model for lymphomagenesis". Hematol. Oncol. Clin. North Am. 18 (4): 863–79, ix. doi:10.1016/j.hoc.2004.04.007. PMID 15325703.
- Noguchi M, Ropars V, Roumestand C, Suizu F (2007). "Proto-oncogene TCL1: more than just a coactivator for Akt". FASEB J. 21 (10): 2273–84. doi:10.1096/fj.06-7684com. PMID 17360849.
- Fu TB, Virgilio L, Narducci MG, et al. (1995). "Characterization and localization of the TCL-1 oncogene product". Cancer Res. 54 (24): 6297–301. PMID 7987816.
- Hoh F, Yang YS, Guignard L, et al. (1998). "Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology". Structure 6 (2): 147–55. doi:10.1016/S0969-2126(98)00017-3. PMID 9519406.
- Takizawa J, Suzuki R, Kuroda H, et al. (1998). "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia". Jpn. J. Cancer Res. 89 (7): 712–8. doi:10.1111/j.1349-7006.1998.tb03275.x. PMID 9738977.
- Pekarsky Y, Hallas C, Isobe M, et al. (1999). "Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2949–51. doi:10.1073/pnas.96.6.2949. PMC 15875. PMID 10077617. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15875.
- Laine J, Künstle G, Obata T, et al. (2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.
- Laine J, Künstle G, Obata T, Noguchi M (2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
- French SW, Shen RR, Koh PJ, et al. (2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry 41 (20): 6376–82. doi:10.1021/bi016068o. PMID 12009899.
- Fears S, Chakrabarti SR, Nucifora G, Rowley JD (2002). "Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression". Cancer Genet. Cytogenet. 135 (2): 110–9. doi:10.1016/S0165-4608(01)00655-0. PMID 12127395.
- Hoyer KK, French SW, Turner DE, et al. (2002). "Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14392–7. doi:10.1073/pnas.212410199. PMC 137894. PMID 12381789. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137894.
- French SW, Malone CS, Shen RR, et al. (2003). "Sp1 transactivation of the TCL1 oncogene". J. Biol. Chem. 278 (2): 948–55. doi:10.1074/jbc.M207166200. PMID 12421830.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Herling M, Teitell MA, Shen RR, et al. (2004). "TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin". Blood 101 (12): 5007–9. doi:10.1182/blood-2002-10-3297. PMID 12576313.
- Kiss C, Nishikawa J, Takada K, et al. (2003). "T cell leukemia I oncogene expression depends on the presence of Epstein–Barr virus in the virus- carrying Burkitt lymphoma lines". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4813–8. doi:10.1073/pnas.0730710100. PMC 153638. PMID 12672960. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=153638.
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