TEF (gene)

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Thyrotrophic embryonic factor
Symbol TEF
External IDs OMIM188595 MGI98663 HomoloGene31140 GeneCards: TEF Gene
RNA expression pattern
PBB GE TEF gnf1h02557 at tn.png
More reference expression data
Species Human Mouse
Entrez 7008 21685
Ensembl ENSG00000167074 ENSMUSG00000022389
UniProt Q10587 Q9JLC6
RefSeq (mRNA) NM_001145398 NM_017376
RefSeq (protein) NP_001138870 NP_059072
Location (UCSC) Chr 22:
41.76 – 41.8 Mb
Chr 15:
81.8 – 81.83 Mb
PubMed search [1] [2]

Thyrotroph embryonic factor is a protein that in humans is encoded by the TEF gene.[1][2][3]

Thyrotroph embryonic factor (TEF), a transcription factor, is a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties.[3]


  1. ^ Khatib ZA, Inaba T, Valentine M, Look AT (Feb 1995). "Chromosomal localization and cDNA cloning of the human DBP and TEF genes". Genomics 23 (2): 344–51. doi:10.1006/geno.1994.1510. PMID 7835883. 
  2. ^ Inukai T, Inaba T, Dang J, Kuribara R, Ozawa K, Miyajima A, Wu W, Look AT, Arinobu Y, Iwasaki H, Akashi K, Kagami K, Goi K, Sugita K, Nakazawa S (May 2005). "TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors". Blood 105 (11): 4437–44. doi:10.1182/blood-2004-08-2976. PMID 15665112. 
  3. ^ a b "Entrez Gene: TEF thyrotrophic embryonic factor". 

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