TEK tyrosine kinase

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TEK tyrosine kinase, endothelial
Protein TEK PDB 1fvr.png
PDB rendering based on 1fvr.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TEK ; CD202B; TIE-2; TIE2; VMCM; VMCM1
External IDs OMIM600221 MGI98664 HomoloGene397 IUPHAR: 1842 ChEMBL: 4128 GeneCards: TEK Gene
EC number
RNA expression pattern
PBB GE TEK 206702 at tn.png
PBB GE TEK 217711 at tn.png
More reference expression data
Species Human Mouse
Entrez 7010 21687
Ensembl ENSG00000120156 ENSMUSG00000006386
UniProt Q02763 Q02858
RefSeq (mRNA) NM_000459 NM_001290549
RefSeq (protein) NP_000450 NP_001277478
Location (UCSC) Chr 9:
27.11 – 27.23 Mb
Chr 4:
94.74 – 94.87 Mb
PubMed search [1] [2]

Angiopoietin-1 receptor is a protein that in humans is encoded by the TEK gene.[1][2]

TEK has also recently been designated CD202B (cluster of differentiation 202B).

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.[3]


TEK tyrosine kinase has been shown to interact with DOK2,[4][5] Angiopoietin 1[6][7][8][9] and ANGPT2.[6][8][9]


  1. ^ Partanen J, Armstrong E, Makela TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Mol Cell Biol 12 (4): 1698–707. PMC 369613. PMID 1312667. 
  2. ^ Boon LM, Mulliken JB, Vikkula M, Watkins H, Seidman J, Olsen BR, Warman ML (February 1995). "Assignment of a locus for dominantly inherited venous malformations to chromosome 9p". Hum Mol Genet 3 (9): 1583–7. doi:10.1093/hmg/3.9.1583. PMID 7833915. 
  3. ^ "Entrez Gene: TEK TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)". 
  4. ^ Jones, N; Dumont D J (September 1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene (ENGLAND) 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. ISSN 0950-9232. PMID 9764820. 
  5. ^ Master, Z; Jones N; Tran J; Jones J; Kerbel R S; Dumont D J (November 2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". EMBO J. (England) 20 (21): 5919–28. doi:10.1093/emboj/20.21.5919. ISSN 0261-4189. PMC 125712. PMID 11689432. 
  6. ^ a b Fiedler, Ulrike; Krissl Tanja, Koidl Stefanie, Weiss Cornelia, Koblizek Thomas, Deutsch Urban, Martiny-Baron Georg, Marmé Dieter, Augustin Hellmut G (January 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". J. Biol. Chem. (United States) 278 (3): 1721–7. doi:10.1074/jbc.M208550200. ISSN 0021-9258. PMID 12427764. 
  7. ^ Davis, S; Aldrich T H, Jones P F, Acheson A, Compton D L, Jain V, Ryan T E, Bruno J, Radziejewski C, Maisonpierre P C, Yancopoulos G D (December 1996). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell (UNITED STATES) 87 (7): 1161–9. doi:10.1016/S0092-8674(00)81812-7. ISSN 0092-8674. PMID 8980223. 
  8. ^ a b Sato, A; Iwama A; Takakura N; Nishio H; Yancopoulos G D; Suda T (August 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". Int. Immunol. (ENGLAND) 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. ISSN 0953-8178. PMID 9723709. 
  9. ^ a b Maisonpierre, P C; Suri C, Jones P F, Bartunkova S, Wiegand S J, Radziejewski C, Compton D, McClain J, Aldrich T H, Papadopoulos N, Daly T J, Davis S, Sato T N, Yancopoulos G D (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science (UNITED STATES) 277 (5322): 55–60. doi:10.1126/science.277.5322.55. ISSN 0036-8075. PMID 9204896. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.