TEK tyrosine kinase

TEK tyrosine kinase, endothelial
	; PDB rendering based on 1fvr.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1FVR, 2GY5, 2GY7, 2OO8, 2OSC, 2P4I, 2WQB, 3BEA, 3L8P, 4K0V
Identifiers
Symbols	TEK; CD202B; TIE-2; TIE2; VMCM; VMCM1
External IDs	OMIM: 600221 MGI: 98664 HomoloGene: 397 ChEMBL: 4128 GeneCards: TEK Gene
EC number	2.7.10.1
Gene Ontology
Molecular function	• protein kinase activity; • protein tyrosine kinase activity; • transmembrane receptor protein tyrosine kinase activity; • receptor activity; • protein binding; • ATP binding;
Cellular component	• stress fiber; • extracellular region; • cytoplasm; • actin filament; • plasma membrane; • integral to plasma membrane; • microvillus; • cell-cell junction; • focal adhesion; • basal plasma membrane; • cell surface; • basolateral plasma membrane; • apical plasma membrane; • membrane raft;
Biological process	• angiogenesis; • positive regulation of protein phosphorylation; • endothelial cell proliferation; • positive regulation of endothelial cell proliferation; • sprouting angiogenesis; • cell-matrix adhesion; • signal transduction; • transmembrane receptor protein tyrosine kinase signaling pathway; • cell-cell signaling; • heart development; • blood coagulation; • positive regulation of endothelial cell migration; • positive regulation of intracellular protein kinase cascade; • positive regulation of phosphatidylinositol 3-kinase cascade; • cell-cell adhesion; • negative regulation of angiogenesis; • peptidyl-tyrosine phosphorylation; • regulation of establishment or maintenance of cell polarity; • positive regulation of peptidyl-serine phosphorylation; • substrate adhesion-dependent cell spreading; • negative regulation of apoptotic process; • regulation of vascular permeability; • positive regulation of phosphatidylinositol 3-kinase activity; • positive regulation of angiogenesis; • protein autophosphorylation; • Tie signaling pathway; • negative regulation of inflammatory response; • leukocyte migration; • protein oligomerization; • positive regulation of focal adhesion assembly; • positive regulation of protein kinase B signaling cascade; • definitive hemopoiesis; • heart trabecula formation; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of actin cytoskeleton reorganization; • regulation of endothelial cell apoptotic process; • negative regulation of endothelial cell apoptotic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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Angiopoietin-1 receptor is a protein that in humans is encoded by the TEK gene.^[1]^[2]

TEK has also recently been designated CD202B (cluster of differentiation 202B).

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.^[3]

Interactions [edit]

TEK tyrosine kinase has been shown to interact with DOK2,^[4]^[5] Angiopoietin 1^[6]^[7]^[8]^[9] and ANGPT2.^[6]^[8]^[9]

References [edit]

^ Partanen J, Armstrong E, Makela TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Mol Cell Biol 12 (4): 1698–707. PMC 369613. PMID 1312667.
^ Boon LM, Mulliken JB, Vikkula M, Watkins H, Seidman J, Olsen BR, Warman ML (February 1995). "Assignment of a locus for dominantly inherited venous malformations to chromosome 9p". Hum Mol Genet 3 (9): 1583–7. doi:10.1093/hmg/3.9.1583. PMID 7833915.
^ "Entrez Gene: TEK TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)".
^ Jones, N; Dumont D J (September 1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene (ENGLAND) 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. ISSN 0950-9232. PMID 9764820.
^ Master, Z; Jones N, Tran J, Jones J, Kerbel R S, Dumont D J (November 2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". EMBO J. (England) 20 (21): 5919–28. doi:10.1093/emboj/20.21.5919. ISSN 0261-4189. PMC 125712. PMID 11689432.
^ ^a ^b Fiedler, Ulrike; Krissl Tanja, Koidl Stefanie, Weiss Cornelia, Koblizek Thomas, Deutsch Urban, Martiny-Baron Georg, Marmé Dieter, Augustin Hellmut G (January 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". J. Biol. Chem. (United States) 278 (3): 1721–7. doi:10.1074/jbc.M208550200. ISSN 0021-9258. PMID 12427764.
^ Davis, S; Aldrich T H, Jones P F, Acheson A, Compton D L, Jain V, Ryan T E, Bruno J, Radziejewski C, Maisonpierre P C, Yancopoulos G D (December 1996). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell (UNITED STATES) 87 (7): 1161–9. doi:10.1016/S0092-8674(00)81812-7. ISSN 0092-8674. PMID 8980223.
^ ^a ^b Sato, A; Iwama A, Takakura N, Nishio H, Yancopoulos G D, Suda T (August 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". Int. Immunol. (ENGLAND) 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. ISSN 0953-8178. PMID 9723709.
^ ^a ^b Maisonpierre, P C; Suri C, Jones P F, Bartunkova S, Wiegand S J, Radziejewski C, Compton D, McClain J, Aldrich T H, Papadopoulos N, Daly T J, Davis S, Sato T N, Yancopoulos G D (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science (UNITED STATES) 277 (5322): 55–60. doi:10.1126/science.277.5322.55. ISSN 0036-8075. PMID 9204896.

External links [edit]

GeneReviews/NCBI/NIH/UW entry on Multiple Cutaneous and Mucosal Venous Malformations

Further reading [edit]

Huang L, Turck CW, Rao P, Peters KG (1995). "GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase.". Oncogene 11 (10): 2097–103. PMID 7478529.
Deans JP, Kalt L, Ledbetter JA, et al. (1995). "Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20.". J. Biol. Chem. 270 (38): 22632–8. doi:10.1074/jbc.270.38.22632. PMID 7545683.
Gallione CJ, Pasyk KA, Boon LM, et al. (1995). "A gene for familial venous malformations maps to chromosome 9p in a second large kindred.". J. Med. Genet. 32 (3): 197–9. doi:10.1136/jmg.32.3.197. PMC 1050316. PMID 7783168.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Dumont DJ, Anderson L, Breitman ML, Duncan AM (1995). "Assignment of the endothelial-specific protein receptor tyrosine kinase gene (TEK) to human chromosome 9p21.". Genomics 23 (2): 512–3. doi:10.1006/geno.1994.1536. PMID 7835909.
Ziegler SF, Bird TA, Schneringer JA, et al. (1993). "Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta.". Oncogene 8 (3): 663–70. PMID 8382358.
Davis S, Aldrich TH, Jones PF, et al. (1997). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.". Cell 87 (7): 1161–9. doi:10.1016/S0092-8674(00)81812-7. PMID 8980223.
Suri C, Jones PF, Patan S, et al. (1997). "Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.". Cell 87 (7): 1171–80. doi:10.1016/S0092-8674(00)81813-9. PMID 8980224.
Vikkula M, Boon LM, Carraway KL, et al. (1997). "Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2.". Cell 87 (7): 1181–90. doi:10.1016/S0092-8674(00)81814-0. PMID 8980225.
Witzenbichler B, Maisonpierre PC, Jones P, et al. (1998). "Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2.". J. Biol. Chem. 273 (29): 18514–21. doi:10.1074/jbc.273.29.18514. PMID 9660821.
Asahara T, Chen D, Takahashi T, et al. (1998). "Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization.". Circ. Res. 83 (3): 233–40. PMID 9710115.
Sato A, Iwama A, Takakura N, et al. (1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells.". Int. Immunol. 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. PMID 9723709.
Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R.". Oncogene 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. PMID 9764820.
De Sepulveda P, Okkenhaug K, Rose JL, et al. (1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.". EMBO J. 18 (4): 904–15. doi:10.1093/emboj/18.4.904. PMC 1171183. PMID 10022833.
Valenzuela DM, Griffiths JA, Rojas J, et al. (1999). "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1904–9. doi:10.1073/pnas.96.5.1904. PMC 26709. PMID 10051567.
Calvert JT, Riney TJ, Kontos CD, et al. (1999). "Allelic and locus heterogeneity in inherited venous malformations.". Hum. Mol. Genet. 8 (7): 1279–89. doi:10.1093/hmg/8.7.1279. PMID 10369874.
Jones N, Master Z, Jones J, et al. (1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.". J. Biol. Chem. 274 (43): 30896–905. doi:10.1074/jbc.274.43.30896. PMID 10521483.
Fachinger G, Deutsch U, Risau W (1999). "Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2.". Oncogene 18 (43): 5948–53. doi:10.1038/sj.onc.1202992. PMID 10557082.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

[pmid1312667-1] Partanen J, Armstrong E, Makela TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Mol Cell Biol 12 (4): 1698–707. PMC 369613. PMID 1312667.

[pmid7833915-2] Boon LM, Mulliken JB, Vikkula M, Watkins H, Seidman J, Olsen BR, Warman ML (February 1995). "Assignment of a locus for dominantly inherited venous malformations to chromosome 9p". Hum Mol Genet 3 (9): 1583–7. doi:10.1093/hmg/3.9.1583. PMID 7833915.

[3] "Entrez Gene: TEK TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)".

[pmid9764820-4] Jones, N; Dumont D J (September 1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene (ENGLAND) 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. ISSN 0950-9232. PMID 9764820.

[pmid11689432-5] Master, Z; Jones N, Tran J, Jones J, Kerbel R S, Dumont D J (November 2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". EMBO J. (England) 20 (21): 5919–28. doi:10.1093/emboj/20.21.5919. ISSN 0261-4189. PMC 125712. PMID 11689432.

[pmid12427764-6] Fiedler, Ulrike; Krissl Tanja, Koidl Stefanie, Weiss Cornelia, Koblizek Thomas, Deutsch Urban, Martiny-Baron Georg, Marmé Dieter, Augustin Hellmut G (January 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". J. Biol. Chem. (United States) 278 (3): 1721–7. doi:10.1074/jbc.M208550200. ISSN 0021-9258. PMID 12427764.

[pmid8980223-7] Davis, S; Aldrich T H, Jones P F, Acheson A, Compton D L, Jain V, Ryan T E, Bruno J, Radziejewski C, Maisonpierre P C, Yancopoulos G D (December 1996). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell (UNITED STATES) 87 (7): 1161–9. doi:10.1016/S0092-8674(00)81812-7. ISSN 0092-8674. PMID 8980223.

[pmid9723709-8] Sato, A; Iwama A, Takakura N, Nishio H, Yancopoulos G D, Suda T (August 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". Int. Immunol. (ENGLAND) 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. ISSN 0953-8178. PMID 9723709.

[pmid9204896-9] Maisonpierre, P C; Suri C, Jones P F, Bartunkova S, Wiegand S J, Radziejewski C, Compton D, McClain J, Aldrich T H, Papadopoulos N, Daly T J, Davis S, Sato T N, Yancopoulos G D (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science (UNITED STATES) 277 (5322): 55–60. doi:10.1126/science.277.5322.55. ISSN 0036-8075. PMID 9204896.

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TEK tyrosine kinase

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