TENC1

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Tensin like C1 domain containing phosphatase (tensin 2)
Protein TENC1 PDB 2dkq.png
PDB rendering based on 2dkq.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TENC1 ; C1-TEN; C1TEN; TNS2
External IDs OMIM607717 MGI2387586 HomoloGene37077 GeneCards: TENC1 Gene
RNA expression pattern
PBB GE TENC1 212494 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23371 209039
Ensembl ENSG00000111077 ENSMUSG00000037003
UniProt Q63HR2 Q8CGB6
RefSeq (mRNA) NM_015319 NM_153533
RefSeq (protein) NP_056134 NP_705761
Location (UCSC) Chr 12:
53.44 – 53.46 Mb
Chr 15:
102.1 – 102.12 Mb
PubMed search [1] [2]

Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.[1]

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[1]

Interactions[edit]

TENC1 has been shown to interact with AXL receptor tyrosine kinase.[2]

References[edit]

  1. ^ a b "Entrez Gene: TENC1 tensin like C1 domain containing phosphatase (tensin 2)". 
  2. ^ Hafizi, Sassan; Alindri Filiz; Karlsson Roger; Dahlbäck Björn (Dec 2002). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. (United States) 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. ISSN 0006-291X. PMID 12470648. 

Further reading[edit]