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Telomerase-associated protein 1
Symbols TEP1 ; TLP1; TP1; TROVE1; VAULT2; p240
External IDs OMIM601686 MGI109573 HomoloGene5157 GeneCards: TEP1 Gene
RNA expression pattern
PBB GE TEP1 205727 at tn.png
More reference expression data
Species Human Mouse
Entrez 7011 21745
Ensembl ENSG00000129566 ENSMUSG00000006281
UniProt Q99973 P97499
RefSeq (mRNA) NM_007110 NM_009351
RefSeq (protein) NP_009041 NP_033377
Location (UCSC) Chr 14:
20.83 – 20.88 Mb
Chr 14:
50.82 – 50.87 Mb
PubMed search [1] [2]

Telomerase protein component 1 is an enzyme that in humans is encoded by the TEP1 gene.[1][2]

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans.[2] It is also a minor vault protein.


  1. ^ Saito T, Matsuda Y, Suzuki T, Hayashi A, Yuan X, Saito M, Nakayama J, Hori T, Ishikawa F (Jan 1998). "Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases". Genomics 46 (1): 46–50. doi:10.1006/geno.1997.5005. PMID 9403057. 
  2. ^ a b "Entrez Gene: TEP1 telomerase-associated protein 1". 

Further reading[edit]