TEP1
From Wikipedia, the free encyclopedia
| Telomerase-associated protein 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TEP1; TLP1; TP1; TROVE1; VAULT2; p240 | ||||||||||||
| External IDs | OMIM: 601686 MGI: 109573 HomoloGene: 5157 GeneCards: TEP1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7011 | 21745 | |||||||||||
| Ensembl | ENSG00000129566 | ENSMUSG00000006281 | |||||||||||
| UniProt | Q99973 | Q3UZN7 | |||||||||||
| RefSeq (mRNA) | NM_007110 | NM_009351.2 | |||||||||||
| RefSeq (protein) | NP_009041 | NP_033377.1 | |||||||||||
| Location (UCSC) | Chr 14: 20.83 – 20.88 Mb |
Chr 14: 51.44 – 51.49 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Telomerase protein component 1 is an enzyme that in humans is encoded by the TEP1 gene.[1][2]
This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans.[2] It is also a minor vault protein.
[edit] References
- ^ Saito T, Matsuda Y, Suzuki T, Hayashi A, Yuan X, Saito M, Nakayama J, Hori T, Ishikawa F (Jan 1998). "Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases". Genomics 46 (1): 46–50. doi:10.1006/geno.1997.5005. PMID 9403057.
- ^ a b "Entrez Gene: TEP1 telomerase-associated protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7011.
[edit] Further reading
- Joly EC, Tremblay E, Tanguay RM et al (1995). "TRiC-P5, a novel TCP1-related protein, is localized in the cytoplasm and in the nuclear matrix". J. Cell. Sci. 107 (10): 2851–9. PMID 7876352.
- Harrington L, McPhail T, Mar V et al (1997). "A mammalian telomerase-associated protein". Science 275 (5302): 973–7. doi:10.1126/science.275.5302.973. PMID 9020079.
- Harrington L, Zhou W, McPhail T et al (1998). "Human telomerase contains evolutionarily conserved catalytic and structural subunits". Genes Dev. 11 (23): 3109–15. doi:10.1101/gad.11.23.3109. PMC 316744. PMID 9389643. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316744.
- Li H, Zhao L, Yang Z et al (1999). "Telomerase is controlled by protein kinase Calpha in human breast cancer cells". J. Biol. Chem. 273 (50): 33436–42. doi:10.1074/jbc.273.50.33436. PMID 9837921.
- Kickhoefer VA, Stephen AG, Harrington L et al (2000). "Vaults and telomerase share a common subunit, TEP1". J. Biol. Chem. 274 (46): 32712–7. doi:10.1074/jbc.274.46.32712. PMID 10551828.
- Li H, Cao Y, Berndt MC et al (2000). "Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro". Oncogene 18 (48): 6785–94. doi:10.1038/sj.onc.1203061. PMID 10597287.
- Koyanagi Y, Kobayashi D, Yajima T et al (2000). "Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells". Anticancer Res. 20 (2A): 773–8. PMID 10810353.
- Beattie TL, Zhou W, Robinson MO, Harrington L (2000). "Polymerization Defects within Human Telomerase Are Distinct from Telomerase RNA and TEP1 Binding". Mol. Biol. Cell 11 (10): 3329–40. PMC 14995. PMID 11029039. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=14995.
- Zhang RG, Zhang RP, Wang XW, Xie H (2004). "Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells". Cell Res. 12 (1): 55–62. doi:10.1038/sj.cr.7290110. PMID 11942411.
- Chang JT, Chen YL, Yang HT et al (2002). "Differential regulation of telomerase activity by six telomerase subunits". Eur. J. Biochem. 269 (14): 3442–50. doi:10.1046/j.1432-1033.2002.03025.x. PMID 12135483.
- Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Zhou JH, Zhang HM, Chen Q et al (2003). "Relationship between telomerase activity and its subunit expression and inhibitory effect of antisense hTR on pancreatic carcinoma". World J. Gastroenterol. 9 (8): 1808–14. PMID 12918126.
- Li C, Wu MY, Liang YR, Wu XY (2003). "Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma". World J. Gastroenterol. 9 (11): 2395–9. PMID 14606063.
- Lim J, Hao T, Shaw C et al (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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