TEP1

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Telomerase-associated protein 1
Identifiers
Symbols TEP1 ; TLP1; TP1; TROVE1; VAULT2; p240
External IDs OMIM601686 MGI109573 HomoloGene5157 GeneCards: TEP1 Gene
RNA expression pattern
PBB GE TEP1 205727 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7011 21745
Ensembl ENSG00000129566 ENSMUSG00000006281
UniProt Q99973 P97499
RefSeq (mRNA) NM_007110 NM_009351
RefSeq (protein) NP_009041 NP_033377
Location (UCSC) Chr 14:
20.83 – 20.88 Mb
Chr 14:
50.82 – 50.87 Mb
PubMed search [1] [2]

Telomerase protein component 1 is an enzyme that in humans is encoded by the TEP1 gene.[1][2]

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans.[2] It is also a minor vault protein.

References[edit]

  1. ^ Saito T, Matsuda Y, Suzuki T, Hayashi A, Yuan X, Saito M, Nakayama J, Hori T, Ishikawa F (Jan 1998). "Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases". Genomics 46 (1): 46–50. doi:10.1006/geno.1997.5005. PMID 9403057. 
  2. ^ a b "Entrez Gene: TEP1 telomerase-associated protein 1". 

Further reading[edit]