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Transcription factor A, mitochondrial
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM600438 MGI107810 HomoloGene31139 GeneCards: TFAM Gene
RNA expression pattern
PBB GE TFAM 203176 s at tn.png
PBB GE TFAM 208541 x at tn.png
PBB GE TFAM 203177 x at tn.png
More reference expression data
Species Human Mouse
Entrez 7019 21780
Ensembl ENSG00000108064 ENSMUSG00000003923
UniProt Q00059 P40630
RefSeq (mRNA) NM_001270782 NM_009360
RefSeq (protein) NP_001257711 NP_033386
Location (UCSC) Chr 10:
60.14 – 60.16 Mb
Chr 10:
71.23 – 71.24 Mb
PubMed search [1] [2]

Mitochondrial transcription factor A, abbreviated as TFAM or mtTFA, is a protein that in humans is encoded by the TFAM gene.[1][2]


This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. TFAM bends mitochondrial promoter DNA to aid transcription of the mitochondrial genome. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells.[2]


TFAM has been shown to interact with TFB1M.[3]


  1. ^ Tiranti V, Rossi E, Ruiz-Carrillo A, Rossi G, Rocchi M, DiDonato S, Zuffardi O, Zeviani M (Jul 1995). "Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis". Genomics 25 (2): 559–64. doi:10.1016/0888-7543(95)80058-T. PMID 7789991. 
  2. ^ a b "Entrez Gene: TFAM transcription factor A, mitochondrial". 
  3. ^ McCulloch, Vicki; Shadel Gerald S (Aug 2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity". Mol. Cell. Biol. (United States) 23 (16): 5816–24. doi:10.1128/MCB.23.16.5816-5824.2003. ISSN 0270-7306. PMC 166325. PMID 12897151. 

Further reading[edit]