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(Redirected from TFDG)
|Jmol-3D images||Image 1|
|Molar mass||868.70 g/mol|
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
- TF-3 is a potent scavenger of superoxide, even more so than EGCG.
- Tea polyphenols including theaflavin TFDG are found to reduce angiogenesis, which is implicated in non-liquid cancers, an area of intense current research, by decreasing vascular endothelial growth factor production and receptor phosphorylation.
- Epigallocatechin gallate (EGCG), a catechin in green tea, binds to gp120, which works in conjunction with gp41, itself blocked by TF-3, both receptors of which HIV hijacks to enter into healthy human immune cells. Therefore, former and latter compounds have considerable potential to block HIV entry, though in real life situations other factors may complicate matters. More studies need to be done. as well as inhibit 3CLPro of severe acute respiratory syndrome (SARS).
- Journal of Agricultural and Food Chemistry:Inhibition of Xanthine Oxidase and Suppression of Intracellular Reactive Oxygen Species in HL-60 Cells by Theaflavin-3,3‘-digallate, (−)-Epigallocatechin-3-gallate, and Propyl Gallate
- Scientific Abstracts: January 2009 Abstracts: Theaflavin - Life Extension
- Chia-Nan Chen1, Coney P. C. Lin, Kuo-Kuei Huang, Wei-Cheng Chen, Hsin-Pang Hsieh, Po-Huang Liang and John T.-A. Hsu (2005). "Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3'-digallate (TF3)". Evidence-based Compl. and Alt. Medicine 2 (2): 209–215. doi:10.1093/ecam/neh081. PMC 1142193. PMID 15937562.