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Transcription factor Dp-1
Protein TFDP1 PDB 2aze.png
PDB rendering based on 2aze.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TFDP1 ; DP1; DRTF1; Dp-1
External IDs OMIM189902 MGI101934 HomoloGene38276 GeneCards: TFDP1 Gene
Species Human Mouse
Entrez 7027 21781
Ensembl ENSG00000198176 ENSMUSG00000038482
UniProt Q14186 Q08639
RefSeq (mRNA) NM_007111 NM_001291765
RefSeq (protein) NP_009042 NP_001278694
Location (UCSC) Chr 13:
114.24 – 114.3 Mb
Chr 8:
13.34 – 13.38 Mb
PubMed search [1] [2]

Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene.[1][2][3]


The E2F transcription factor family (see MIM 189971) regulates the expression of various cellular promoters, particularly those involved in the cell cycle. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription factors; see TFDP2 (MIM 602160).[supplied by OMIM][3]


TFDP1 has been shown to interact with:


  1. ^ Girling R, Partridge JF, Bandara LR, Burden N, Totty NF, Hsuan JJ et al. (Nov 1993). "A new component of the transcription factor DRTF1/E2F". Nature 365 (6445): 468. doi:10.1038/365468d0. PMID 8413592. 
  2. ^ Zhang Y, Venkatraj VS, Fischer SG, Warburton D, Chellappan SP (Mar 1997). "Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family". Genomics 39 (1): 95–8. doi:10.1006/geno.1996.4473. PMID 9027491. 
  3. ^ a b "Entrez Gene: TFDP1 transcription factor Dp-1". 
  4. ^ a b Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A et al. (Mar 1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2403–7. doi:10.1073/pnas.92.6.2403. PMC 42492. PMID 7892279. 
  5. ^ Suzuki M, Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T et al. (Aug 1998). "A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer". Oncogene 17 (7): 853–65. doi:10.1038/sj.onc.1202163. PMID 9780002. 
  6. ^ Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA (May 1995). "In vivo association of E2F and DP family proteins". Mol. Cell. Biol. 15 (5): 2536–46. PMC 230484. PMID 7739537. 
  7. ^ Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C et al. (Oct 1993). "Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation". Genes Dev. 7 (10): 1850–61. doi:10.1101/gad.7.10.1850. PMID 8405995. 
  8. ^ Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (Jun 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Mol. Cell. Biol. 15 (6): 3082–9. PMC 230539. PMID 7760804. 
  9. ^ Sørensen TS, Girling R, Lee CW, Gannon J, Bandara LR, La Thangue NB (Oct 1996). "Functional interaction between DP-1 and p53". Mol. Cell. Biol. 16 (10): 5888–95. PMC 231590. PMID 8816502. 

Further reading[edit]