From Wikipedia, the free encyclopedia
Jump to: navigation, search
Transforming growth factor beta 1 induced transcript 1
Symbols TGFB1I1 ; ARA55; HIC-5; HIC5; TSC-5
External IDs OMIM602353 MGI102784 HomoloGene7572 GeneCards: TGFB1I1 Gene
RNA expression pattern
PBB GE TGFB1I1 209651 at tn.png
More reference expression data
Species Human Mouse
Entrez 7041 21804
Ensembl ENSG00000140682 ENSMUSG00000030782
UniProt O43294 Q62219
RefSeq (mRNA) NM_001042454 NM_001289550
RefSeq (protein) NP_001035919 NP_001276479
Location (UCSC) Chr 16:
31.48 – 31.49 Mb
Chr 7:
128.25 – 128.25 Mb
PubMed search [1] [2]

Transforming growth factor beta-1-induced transcript 1 protein is a protein that in humans is encoded by the TGFB1I1 gene.[1][2]


TGFB1I1 has been shown to interact with PTPN12,[3] PTK2,[1][4][5] Androgen receptor,[6][7] PTK2B,[1][5][6] Dopamine transporter[8] and Hsp27.[9]

See also[edit]


  1. ^ a b c Matsuya M, Sasaki H, Aoto H, Mitaka T, Nagura K, Ohba T, Ishino M, Takahashi S, Suzuki R, Sasaki T (February 1998). "Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions". J Biol Chem 273 (2): 1003–14. doi:10.1074/jbc.273.2.1003. PMID 9422762. 
  2. ^ Fujimoto N, Yeh S, Kang HY, Inui S, Chang HC, Mizokami A, Chang C (April 1999). "Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate". J Biol Chem 274 (12): 8316–21. doi:10.1074/jbc.274.12.8316. PMID 10075738. 
  3. ^ Nishiya, N; Iwabuchi Y; Shibanuma M; Côté J F; Tremblay M L; Nose K (April 1999). "Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain". J. Biol. Chem. (UNITED STATES) 274 (14): 9847–53. doi:10.1074/jbc.274.14.9847. ISSN 0021-9258. PMID 10092676. 
  4. ^ Nishiya, N; Tachibana K; Shibanuma M; Mashimo J I; Nose K (August 2001). "Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase". Mol. Cell. Biol. (United States) 21 (16): 5332–45. doi:10.1128/MCB.21.16.5332-5345.2001. ISSN 0270-7306. PMC 87257. PMID 11463817. 
  5. ^ a b Thomas, S M; Hagel M; Turner C E (January 1999). "Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin". J. Cell. Sci. (ENGLAND) 112 (2): 181–90. ISSN 0021-9533. PMID 9858471. 
  6. ^ a b Wang, Xin; Yang Yue; Guo Xiaojian; Sampson Erik R; Hsu Cheng-Lung; Tsai Meng-Yin; Yeh Shuyuan; Wu Guan; Guo Yinglu; Chang Chawnshang (May 2002). "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator". J. Biol. Chem. (United States) 277 (18): 15426–31. doi:10.1074/jbc.M111218200. ISSN 0021-9258. PMID 11856738. 
  7. ^ He, Bin; Minges John T; Lee Lori W; Wilson Elizabeth M (March 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". J. Biol. Chem. (United States) 277 (12): 10226–35. doi:10.1074/jbc.M111975200. ISSN 0021-9258. PMID 11779876. 
  8. ^ Carneiro, Ana M; Ingram Susan L; Beaulieu Jean-Martin; Sweeney Ava; Amara Susan G; Thomas Sheila M; Caron Marc G; Torres Gonzalo E (August 2002). "The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter". J. Neurosci. (United States) 22 (16): 7045–54. PMID 12177201. 
  9. ^ Jia, Y; Ransom R F; Shibanuma M; Liu C; Welsh M J; Smoyer W E (October 2001). "Identification and characterization of hic-5/ARA55 as an hsp27 binding protein". J. Biol. Chem. (United States) 276 (43): 39911–8. doi:10.1074/jbc.M103510200. ISSN 0021-9258. PMID 11546764. 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.