TGF beta 2

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Transforming growth factor, beta 2
Protein TGFB2 PDB 1tfg.png
PDB rendering based on 1tfg.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TGFB2 ; LDS4; TGF-beta2
External IDs OMIM190220 MGI98726 HomoloGene2432 GeneCards: TGFB2 Gene
RNA expression pattern
PBB GE TGFB2 209908 s at tn.png
PBB GE TGFB2 209909 s at tn.png
PBB GE TGFB2 220407 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7042 21808
Ensembl ENSG00000092969 ENSMUSG00000039239
UniProt P61812 P27090
RefSeq (mRNA) NM_001135599 NM_009367
RefSeq (protein) NP_001129071 NP_033393
Location (UCSC) Chr 1:
218.52 – 218.62 Mb
Chr 1:
186.62 – 186.71 Mb
PubMed search [1] [2]

Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development (alternative names: Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin). It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. There are two named isoforms of this protein, created by alternative splicing of the same gene.

Further reading[edit]