TH1L

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Negative elongation factor complex member C/D
Identifiers
Symbols NELFCD ; NELF-C; NELF-D; TH1; TH1L
External IDs OMIM605297 MGI1926424 HomoloGene9496 GeneCards: NELFCD Gene
RNA expression pattern
PBB GE TH1L 220607 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51497 57314
Ensembl ENSG00000101158 ENSMUSG00000016253
UniProt Q8IXH7 Q922L6
RefSeq (mRNA) NM_016397 NM_020580
RefSeq (protein) NP_945327 NP_065605
Location (UCSC) Chr 20:
57.56 – 57.57 Mb
Chr 2:
174.42 – 174.43 Mb
PubMed search [1] [2]

Negative elongation factor C/D is a protein that in humans is encoded by the TH1L gene.[1][2][3]

The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini.[3]

Interactions[edit]

TH1L has been shown to interact with RDBP,[4][5] ARAF[6][7] and Cofactor of BRCA1.[4][5]

References[edit]

  1. ^ Bonthron DT, Hayward BE, Moran V, Strain L (Oct 2000). "Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13". Hum Genet 107 (2): 165–75. doi:10.1007/s004390000344. PMID 11030415. 
  2. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. 
  3. ^ a b "Entrez Gene: TH1L TH1-like (Drosophila)". 
  4. ^ a b Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  5. ^ a b Narita, Takashi; Yamaguchi Yuki, Yano Keiichi, Sugimoto Seiji, Chanarat Sittinan, Wada Tadashi, Kim Dong-ki, Hasegawa Jun, Omori Masashi, Inukai Naoto, Endoh Masaki, Yamada Tomoko, Handa Hiroshi (Mar 2003). "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex". Mol. Cell. Biol. (United States) 23 (6): 1863–73. doi:10.1128/MCB.23.6.1863-1873.2003. ISSN 0270-7306. PMC 149481. PMID 12612062. 
  6. ^ Yuryev, Anton; Wennogle Lawrence P (Feb 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics (United States) 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN 0888-7543. PMID 12620389. 
  7. ^ Yin, Xiang L; Chen She; Gu Jian X (Feb 2002). "Identification of TH1 as an interaction partner of A-Raf kinase". Mol. Cell. Biochem. (Netherlands) 231 (1-2): 69–74. doi:10.1023/A:1014437024129. ISSN 0300-8177. PMID 11952167. 

Further reading[edit]