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Thrombospondin 4
Symbols THBS4 ; TSP4
External IDs OMIM600715 MGI1101779 HomoloGene20691 GeneCards: THBS4 Gene
RNA expression pattern
PBB GE THBS4 204776 at tn.png
More reference expression data
Species Human Mouse
Entrez 7060 21828
Ensembl ENSG00000113296 ENSMUSG00000021702
UniProt P35443 Q9Z1T2
RefSeq (mRNA) NM_003248 NM_011582
RefSeq (protein) NP_003239 NP_035712
Location (UCSC) Chr 5:
79.29 – 79.38 Mb
Chr 13:
92.75 – 92.79 Mb
PubMed search [1] [2]

Thrombospondin-4 is a protein that in humans is encoded by the THBS4 gene.[1][2]

The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system.[2]


  1. ^ Lawler J, McHenry K, Duquette M, Derick L (Mar 1995). "Characterization of human thrombospondin-4". J Biol Chem 270 (6): 2809–14. doi:10.1074/jbc.270.6.2809. PMID 7852353. 
  2. ^ a b "Entrez Gene: THBS4 thrombospondin 4". 

Further reading[edit]