Tetrahydrocannabinolic acid synthase

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Tetrahydrocannabinolic acid synthase
Identifiers
EC number 1.21.3.7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Tetrahydrocannabinolic acid synthase (EC 1.21.3.7, THCA synthase, Delta1-tetrahydrocannabinolic acid synthase) is an enzyme with system name cannabigerolate:oxygen oxidoreductase (cyclizing, Delta9-tetrahydrocannabinolate-forming).[1][2][3][4] This enzyme catalyses the following chemical reaction

cannabigerolate + O2 \rightleftharpoons Delta9-tetrahydrocannabinolate + H2O2

Tetrahydrocannabinolic acid synthase is a flavoprotein (FAD).

References[edit]

  1. ^ Taura, F., Morimoto, S. Shoyama, Y. and Mechoulam, R. (1995). "First direct evidence for the mechanism of Δ1-tetrahydrocannabinolic acid biosynthesis". J. Am. Chem. Soc. 117: 9766–9767. doi:10.1021/ja00143a024. 
  2. ^ Sirikantaramas, S., Morimoto, S., Shoyama, Y., Ishikawa, Y., Wada, Y., Shoyama, Y. and Taura, F. (2004). "The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Δ1-tetrahydrocannabinolic acid synthase from Cannabis sativa L". J. Biol. Chem. 279 (38): 39767–39774. doi:10.1074/jbc.M403693200. PMID 15190053. 
  3. ^ Shoyama, Y., Takeuchi, A., Taura, F., Tamada, T., Adachi, M., Kuroki, R., Shoyama, Y. and Morimoto, S. (2005). "Crystallization of Δ1-tetrahydrocannabinolic acid (THCA) synthase from Cannabis sativa". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (Pt 8): 799–801. doi:10.1107/S1744309105023365. PMID 16511162. 
  4. ^ Shoyama, Y., Tamada, T., Kurihara, K., Takeuchi, A., Taura, F., Arai, S., Blaber, M., Shoyama, Y., Morimoto, S. and Kuroki, R. (2012). "Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa". J. Mol. Biol. 423 (1): –. doi:10.1016/j.jmb.2012.06.030. PMID 22766313. 

External links[edit]