Tetrahydrocannabinolic acid synthase

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Tetrahydrocannabinolic acid synthase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Tetrahydrocannabinolic acid synthase (EC, THCA synthase, Delta1-tetrahydrocannabinolic acid synthase) is an enzyme with system name cannabigerolate:oxygen oxidoreductase (cyclizing, Delta9-tetrahydrocannabinolate-forming).[1][2][3][4] This enzyme catalyses the following chemical reaction

cannabigerolate + O2 \rightleftharpoons Delta9-tetrahydrocannabinolate + H2O2

Tetrahydrocannabinolic acid synthase is a flavoprotein (FAD).


  1. ^ Taura, F., Morimoto, S. Shoyama, Y. and Mechoulam, R. (1995). "First direct evidence for the mechanism of Δ1-tetrahydrocannabinolic acid biosynthesis". J. Am. Chem. Soc. 117: 9766–9767. doi:10.1021/ja00143a024. 
  2. ^ Sirikantaramas, S., Morimoto, S., Shoyama, Y., Ishikawa, Y., Wada, Y., Shoyama, Y. and Taura, F. (2004). "The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Δ1-tetrahydrocannabinolic acid synthase from Cannabis sativa L". J. Biol. Chem. 279 (38): 39767–39774. doi:10.1074/jbc.M403693200. PMID 15190053. 
  3. ^ Shoyama, Y., Takeuchi, A., Taura, F., Tamada, T., Adachi, M., Kuroki, R., Shoyama, Y. and Morimoto, S. (2005). "Crystallization of Δ1-tetrahydrocannabinolic acid (THCA) synthase from Cannabis sativa". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (Pt 8): 799–801. doi:10.1107/S1744309105023365. PMID 16511162. 
  4. ^ Shoyama, Y., Tamada, T., Kurihara, K., Takeuchi, A., Taura, F., Arai, S., Blaber, M., Shoyama, Y., Morimoto, S. and Kuroki, R. (2012). "Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa". J. Mol. Biol. 423 (1): –. doi:10.1016/j.jmb.2012.06.030. PMID 22766313. 

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