TIA1

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TIA1 cytotoxic granule-associated RNA binding protein
Identifiers
Symbol TIA1
Entrez 7072
HUGO 11802
OMIM 603518
RefSeq NM_022173
UniProt P31483
Other data
Locus Chr. 2 p13

TIA1 is a 3'UTR mRNA binding protein and can bind the 5'TOPsequence of 5'TOP mRNAs. It is associated with programmed cell death (apoptosis) and regulates alternative splicing of the gene encoding the Fas receptor, an apoptosis-promoting protein.[1]

Notes[edit]

  1. ^ Izquierdo JM, Majós N, Bonnal S, et al (August 2005). "Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon definition". Mol. Cell 19 (4): 475–84. doi:10.1016/j.molcel.2005.06.015. PMID 16109372. 

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