From Wikipedia, the free encyclopedia
Jump to: navigation, search
TGFB1-induced anti-apoptotic factor 1
Symbols TIAF1 ; MAJN; SPR210
External IDs OMIM609517 HomoloGene130531 GeneCards: TIAF1 Gene
Species Human Mouse
Entrez 9220 n/a
Ensembl ENSG00000221995 n/a
UniProt O95411 n/a
RefSeq (mRNA) NM_004740 n/a
RefSeq (protein) NP_004731 n/a
Location (UCSC) Chr 17:
27.4 – 27.42 Mb
PubMed search [1] n/a

TGFB1-induced anti-apoptotic factor 1 is a protein that in humans is encoded by the TIAF1 gene.[1][2]


TIAF1 has been shown to interact with Janus kinase 3[3] and TRIB3.[4]


  1. ^ Chang NS, Mattison J, Cao H, Pratt N, Zhao Y, Lee C (February 1999). "Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity". Biochem Biophys Res Commun 253 (3): 743–9. doi:10.1006/bbrc.1998.9846. PMID 9918798. 
  2. ^ "Entrez Gene: TIAF1 TGFB1-induced anti-apoptotic factor 1". 
  3. ^ Ji, H; Zhai Q; Zhu J; Yan M; Sun L; Liu X; Zheng Z (April 2000). "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival". Biochem. Biophys. Res. Commun. (UNITED STATES) 270 (1): 267–71. doi:10.1006/bbrc.2000.2413. ISSN 0006-291X. PMID 10733938. 
  4. ^ Zhou, Ying; Li Lu; Liu Qiongming; Xing Guichun; Kuai Xuezhang; Sun Jing; Yin Xiushan; Wang Jian; Zhang Lingqiang; He Fuchu (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. (England) 20 (5): 942–8. doi:10.1016/j.cellsig.2008.01.010. ISSN 0898-6568. PMID 18276110. 

Further reading[edit]